Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
What kind of molecules are receptors? Where are they found?
|
Protein molecules. Mostly on the plasma membrane, but also some in the nuclear membrane.
|
|
|
What are the typical shapes of dose-response curves and log dose-response curves?
|
A plateauing curve and sigmoidal, respectively.
|
|
|
What is the ED50 of a drug?
|
The dose that will produce a defined response in half of the population.
|
|
|
What is the TD50 of a drug?
|
The dose that will produce a defined toxic response in half the population.
|
|
|
What is the problem with giving higher doses to overcome lower potency?
|
Higher doses also provide a higher chemical load and toxicities.
|
|
|
How do you calculate the therapeutic index of a drug?
|
TI = TD50 / ED50.
|
|
|
What are some different effects that can be had by an antagonist?
|
Interaction with a receptor without stimulation or transduction, prevention of the effects of an agonist, and responses elicited due to preventing the action of an agonist.
|
|
|
What is a full agonist? Do they all give the same curve?
|
A drug that gives a maximal response (efficacy of 1). They can vary in affinity, though, shifting the curve right as affinity decreases.
|
|
|
What does the curve of a partial agonist/antagonist look like compared to a full agonist?
|
Shifted right and sloped more to the right.
|
|
|
What is a competitive antagonist? What is its effect on the D/R curve?
|
It combines with the same receptor as the agonist. It shift the curve right, but still parallel to the full agonist.
|
|
|
What kind of shift of D/R curve does an irreversible agonist promote? What if the dose is increased?
|
It shifts it right, and angling more to the right. This is increased when dosage is increased.
|
