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11 Cards in this Set

  • Front
  • Back
What kind of molecules are receptors? Where are they found?
Protein molecules. Mostly on the plasma membrane, but also some in the nuclear membrane.
What are the typical shapes of dose-response curves and log dose-response curves?
A plateauing curve and sigmoidal, respectively.
What is the ED50 of a drug?
The dose that will produce a defined response in half of the population.
What is the TD50 of a drug?
The dose that will produce a defined toxic response in half the population.
What is the problem with giving higher doses to overcome lower potency?
Higher doses also provide a higher chemical load and toxicities.
How do you calculate the therapeutic index of a drug?
TI = TD50 / ED50.
What are some different effects that can be had by an antagonist?
Interaction with a receptor without stimulation or transduction, prevention of the effects of an agonist, and responses elicited due to preventing the action of an agonist.
What is a full agonist? Do they all give the same curve?
A drug that gives a maximal response (efficacy of 1). They can vary in affinity, though, shifting the curve right as affinity decreases.
What does the curve of a partial agonist/antagonist look like compared to a full agonist?
Shifted right and sloped more to the right.
What is a competitive antagonist? What is its effect on the D/R curve?
It combines with the same receptor as the agonist. It shift the curve right, but still parallel to the full agonist.
What kind of shift of D/R curve does an irreversible agonist promote? What if the dose is increased?
It shifts it right, and angling more to the right. This is increased when dosage is increased.