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20 Cards in this Set
- Front
- Back
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Clopidogrel (Plavix) & Ticlopidine (Ticlid) work where?
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At the ADP receptor
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How much does aspirin prevent vascular death?
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15%
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How much does aspirin prevent nonfatal vascular death?
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30%
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What is the MOA of aspirin?
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blocks cyclooxygenase
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What dosage should be given to patients with acute ischemic stroke?
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160 mg
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What dose of aspirin should be given to patients with TIA & ischemic stroke?
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50 mg
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What dose of aspirin should be given to men with a high cardiovascular event risk?
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75 mg
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What are the thienopyridines?
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Clopidogrel
Prasugrel Ticlopidine |
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What severe adverse effects are responsible for the decreased use of thienopyridines?
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Thrombocytopenia
Aplastic anemia TTP |
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What is the MOA of thienopyridines?
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inhibit ADP induced platelet aggregation
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What are the oral anticoagulants?
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Warfarin (Coumadin)
Dabigatran |
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What are the subcutaneous anticoagulants?
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LMWH (Enoxaparin, Dalteparin)
Fondaparinux (Arixtra) Heparin |
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What are the IV anticoagulants?
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Heparin
Direct Thrombin Inhibitors (Argatroban, Lepirudin, Bivalrudin) |
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What is the MOA of warfarin (Coumadin)?
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blocks the vitamin K dependent glutamate carboxylation of precursor clotting factors (2, 7, 9, 10)
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How long does it take before a patient on warfarin (Coumadin) is fully anticoagulated?
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2-3 days
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What dosage of heparin is given for DVT prophylaxis?
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5000 U SQ TID
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What is the dosage for weight-based treatment dosing?
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80 U/kg bolus and 18 U/kg/hr
Titrate to desired aPTT |
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What are the direct thrombin inhibitors?
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Argatroban
Lepirudin (Refludan) Bivalrudin (Angiomax) |
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What is the MOA of thrombolytics?
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Converts plasminogen to plasmin
Converts fibrin to fibrin degradation products (tissue plasminogen activator) |
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What is the only thrombolytic agent approved by the FDA for treatment of acute ischemic stroke?
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IV tPA
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