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13 Cards in this Set
- Front
- Back
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Sandroni hypertension
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lack of compliance in the arterial tree
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where does resistance develop in htn?
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arterioles (connects artery and capillary), muscular
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eNOS vs NOX
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eNOS: vasorelaxation (cGMP)
NOX: Vasoconstriction (superoxides) |
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Asymmetric dimerthylarginine (ADMA)
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inhibitor of NO synthesis (we want this bc its a short acting relaxer)
this compound is elevated in pts w lots of htn related dz |
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obesity relationship to htn
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obesity associated w systemic inflammatory response (endothelial cell dysfunction, oxidase stress, activation of circulating immune cells) adiposecytes release cytokines (leptin, resistin) that mediates inflammation accompanying obesity
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carotid sinus stimulation
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lower bp
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regular slow breathing
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exercise lowers bp and breathing patterns at rest
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those at highest risk for coronary heart disease
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those that are also insulin resistant
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how to measure endothelial dysfnction
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can see how well a vascular tree will conduct an impedence wave
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secondary causes of htn
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renal artery (stenosis (fibromuscular dysplasia - young womne/ artheroscleortic (older males)
hyperaldosteronism (from bilateral adrenal hyperplasia or an adenoma usually but not always accompanied by hypokalemia) renal insuficiency Cushing's Disease hypothyroidism hyperthyroidism obstructive sleep apnea coarctation of the aorta |
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htn cutoffs
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>140 htn
>130 prehtn <130 = normotensive |
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causes of htn in extremes of age
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secondary causes (fibromuscular dysplasia in young woman)
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mc reason for hypertension in older person
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bp goes up with age
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