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24 Cards in this Set
- Front
- Back
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Subepithelial deposition
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Beneath podocytes
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Below basement membrane, above endothelial
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Subendothelial deposition
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Why differential location of IC?
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Big complexes in mesangium bc cant penetrate GBM
Small complexes can reach subepithelial levels |
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Glycation
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Linking glucose to proteins; non-enzymatic glycosylation; proteins dont work properly
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non-specific progression of renal fibrosis
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important bc fibrosis likely proceeds the same in many different diseases
chronic exposure to insults |
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mesangiolysis with loss of tight capillary loops; loss of structure/arrangement of tight capillary loops
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progression of mesangiolysis to ballooning
restoration towards normal architecture |
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disruption of urinary space with cellular bridging
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insudation of protein and inflammatory cells into urinary space
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disruption of tubular architecture as well as further glomeular damage
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complete disruption of tubular structure...if even the glomerulus
recovers it will now be unable to function |
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active sediment
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cells in cast
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bland sediment
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no cells/cast
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proteinuria, bland or chronic sediment, stable or slowly creatinine
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chronic glomerulonephritis
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proteinuria, active sediment, progressive rapid rise in creatinine
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rapidly progressive eglomerulonephritis
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IgA neprhopathy
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Women: gross hematuria
Men: microhematuria |
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FARF
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functional acute renal failure;
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no proteinuria, bland or hyaline casts in segiment, elevated creatinine
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functional acute renal failur
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No proteinuria, sediment
with casts, debris, and renal tubular epithelial cells |
• acute tubular necrosis
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No proteinuria, bland
or “chronic” sediment, stable elevated or slowly rising creatinine |
• chronic tubulo-
interstitial nephropathy |
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No proteinuria, WBC’s
in urine with or without bacteria |
• infection
• acute interstitial nephritis |
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differentiation between glomerular and tubular disease
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whether or not there is protein in the urine
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lupus demographic
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young black females
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what occurs in toxic insult to kidney
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1. Vasospasm; reduces flow of blood into glomerulus
2. Backleak of filtrate into interstitium, cant form urine 3. Obstruction (due to casts of sloughed off cells) |
