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222 Cards in this Set

  • Front
  • Back

Respiratory System

body system bringing oxygen from the air into the body for delivery via the blood to the cells

Respiration

exchange of gases (Oxygen and Carbon Dioxide) between the atmosphere and the cells of the body

Ventilation

term used to describe the bringing in of fresh air

What makes up the upper respiratory tract?

Nostrils, Nose, Nasal Cavities, Pharynx, and Larynx

What makes up the lower respiratory tract?

Trachea, Bronchi, Bronchioles, and Alveoli

What do Expectorants do?

increase the flow of respiratory secretions to allow material to be coughed up from the lungs by increasing the fluidity of mucus, which is more effectively coughed up than thicker mucus or by reducing the stickiness of the mucus; also helps keep dry, irritated tissue moist

What is an example of an Expectorant?

Guaifenesin

Describe Guaifensin

*Glyceryl guaiacolate


*dual-purpose


*rapid onset of action


*used orally as an expectorant


*given IV as a muscle relaxer in hourses as part of general anesthesia protocol


*minimal effect on sedation

What are side effects of Guaifensin?

hypotension, tachycardia, thrombophlebitis

What do mucolytic drugs do?

Decrease viscosity or thickness of respiratory secretions

What is an example of mucolytic drugs?

Acetylcysteine (Mucosol, Mucomyst, Mucinex)

What is Acetylcysteine used for?

break up thick mucoid secretions in the airway to promote better respiration and acetaminophen toxicity in cats

Describe Acetylcysteine

*administered orally, IV, or as an aerosol through nebulization


*mucolytic expectorant


*also used as an antidote

What are side effects of Acetylcysteine?

vomiting, hypersensitivity, bronchiole constriction

What are antitussives used for?

suppress coughing

How do antitussives work?

Centrally acting or locally acting

What do centrally acting antitussives work on?

working on the cough centers of the brain stem

What do locally acting antitussives work on?

soothing irritation to the mucosal lining of the respiratory tract that initiates coughing

What are examples of antitussives?

*Butorphanol (Torbugesic, Torbutrol)


*Hydrocodone (Hycodan, Tussigon)


*Codeine


*Dextromethorphan


*Trimeprazine

Describe Butorphanol

*centrally acting antitussive


*used as preanesthetic and analgesic


*C-IV controlled substance


*injectable and oral tablet

What are side effects of Butorphanol?

sedation, ataxia, respiratory depression, and bradycardia

Describe Hydrocodone

*C-III controlled substance


*centrally acting narcotic


*tablet and syrup forms


*used primarily for harsh, nonproductive coughs such as kennel cough

What are side effects of Hydrocodone?

sedation and slowing of gastrointestinal motility

Describe Codeine

*C-II controlled substance


*centrally acting


*injectable, syrup, and tablet forms

What are side effects of Codeine?

sedation and decreased gastrointestinal motility

What two drugs form the LorTab and what scheduled class is it?

Hydrocodone and acetaminophen; C-II

Describe Dextromethorphan

*nonnarcotic


*centrally acting


*OTC available


*Rare in Vet medicine; may be harmful to animals

Describe Trimeprazine

*centrally acting antitussive


*found in combination with Prednisolone (a glucocorticoid) to form Temaril-P


*antipruritic effects


*tablets

What are side effects of Trimeprazine?

sedation, depression, and hypotension

Describe Temaril-P

*nonnarcotic


*centrally acting

What do decongestants do?

Decrease congestion of nasal passages by reducing swelling

Describe decongestants

*spray or orally as liquid or tablet


*limited use in vet practice


*used to help treat feline upper respiratory tract disease

What are examples of decongestants?

*Phenylephrine (Neo-Synephrine)


*Pseudoephedrine (Sudafed)

Phenylephrine (Neo-Synephrine)

*nasal spray


*SE: cardio stimulatory properties


*should not be used in animals with hypertension or tachycardia

Pseudoephedrine (Sudafed)

*tablet


*pharmacy permission required


*system

Describe Bronchodilators

*widen the lumen of the bronchioles and counteract bronchoconstriction


*cause increased respiratory secretions

What are the 4 types of Bronchodilators?

*Cholinergic Blocking Agents


*Beta-2-adrenergic agonists


*Methylxanthines


*Antihistamines

Describe Cholinergic Blocking Agents and list their side effects

*commonly known as anticholinergics


*dry mouth, dry eyes, tachycardia

What are examples of cholinergic agents?

Atropine and Glycopyrrolate

What are extra side effects caused by Atropine?

vomiting, constipation, and urinary retention

What is atropine common for?

pre-anesthetic

What are examples of beta-2-adrenergic agonists?

*Epinephrine


*Albuterol

Describe Epinephrine

*usually reserved for life-threatening situations and has beta-1 and alpha-1 activity


*stimulation for contraction of heart & supports circulatory system after cardiac arrest


*human medication

Describe Albuterol

*common in equine for COPD


*used also for feline asthma


*nebulized form

What are side effects of beta-2-adrenergic agonists?

tachycardia and CNS excitement and weakness

Describe Methylxanthines and its side effects

*limited use because of narrow therapeutic index


*SE: CNS stimulation and GI irritation

What do antihistamines do?

Block the effects of histamine

What are antihistamines used for?

*prevention of respiratory problems such as heaves in horses (but is very expensive) and feline asthma


*allergic reactions and daily allergies in small animals

What are side effects of antihistamines?

CNS depression and anticholinergic effects (dry mouth and urinary retention)

what are Respiratory Stimulants?

drugs that stimulate the animal to increase its respirations

What is an example of a respiratory stimulant?

Doxapram, Naloxone, Yohimbine


Describe Doxapram

*central nervous stimulant


*usually used in neonates to stimulate respiration after a C-section or dystocia


*also used to restore reflexes, speed awakenings, & restoration after anesthesia


*injectable as Dopram-V

What are side effects of Doxapram?

hypertension, arrhythmias, and seizures

Naloxone

increases respiration in narcotic overdose

Yohimbine

stimulates respiration in Xylazine overdose

What are 4 terms used to describe a long, muscular tube that begins at the mouth and ends at the anus?

Gastrointestinal tract, alimentary system, GI tract, Digestive Tract

What are the anatomic structures of the GI tract?

oral cavity, pharynx, esophagus, stomach, small intestine, and large intestine

What is one control mechanism of the GI tract?

autonomic nervous system

What are the 2 branches of the autonomic nervous system?

parasympathetic and sympathetic

Describe the parasympathetic branch

*homeostatic response


*increases intestinal motility and GI secretions and relaxes sphincters

Describe Sympathetic Branch

*decreases intestinal motility, decreases intestinal secretions, and inhibits the action of sphincters

What drugs stimulate parasympathetic actions?

Cholinergic drugs

What drugs inhibit parasympathetic actions?

Anticholinergic drugs

What drugs stimulate sympathetic actions?

sympathetic drugs

Describe Antisialogues

*drugs used to decrease salivary flow


*given IV, IM, or SQ to limit excess saliva productions

What are 2 examples of Antisialogues?

Atropine and Glycopyrrolate

How are Atropine and Glycopyrrolate Antisialogues?

Via their anticholinergic mechanism of action

What are the side effects of antisialogues?

dry mouth, constipation, CNS stimulation, tachycardia, pupillary dilation, can effect peristalsis and secretions for proper GI functions

What are Antidiarrheals?

drugs that decrease peristalsis of the gastrointestinal tract, thereby allowing fluid absorption from the intestinal contents

What are the 5 categories of Antidiarrheals?

*Anticholinergics


*Protectants/Adsorbents


*Opiate-related agents


*Probiotics


*Metronidazole

What are Anticholinergics?

used to treat tenesmus (straining to defecate) associated with colitis and vomiting related to colonic irritation

What are side effects of Anticholinergic drugs?

dry mucous membranes, urine retention, tachycardia, and constipation

What are examples of Anticholinergics?

*Atropine (generic, Atropine Injectable-SA, Atropine Injectable-LA)


*Aminopentamide (Centrine)


*Propantheline (Pro-Banthine)


*Methscopolamine (Biosol-M)


*N-butylscopolammonium Bromide (Buscopan)

Describe Protectants

*work by binding bacteria and/or digestive enzymes and/or toxins to protect intestinal mucosa from their damaging effects

Describe Adsorbents

*they bind substances

What are side effects of protectants/adsorbents?

*uncommon


*can cause black poop

What are examples of protectants/adsorbents?

*bismuth subsalicylate (Pepto-Bismol)


*kaolin/pectin (Kao-Forte)


*activated charcoal (Liqui-Char, Superchar)

Describe the bismuth portion of Bismuth Subsalicylate (Pepto-Bismol)
coats the intestinal mucosa and has antiendotoxic and weak antibacterial effects

Describe the Subsalicylate portion of bismuth subsalicylate

has anti-inflammatory effects; aspirin-like product; do not give to cats

What are side effects of bismuth subsalicylate?

blacken stool and tongue; binds to bacteria toxins, or digestive enzymes

Describe Opiate-related agents

*these or narcotic analgesics control diarrhea by decreasing both intestinal secretions and the flow of feces, and increasing segmental contractions, thereby resulting in increased intestinal absorption

What are side effects of Opiate-related agents?

CNS depression (excitement in horses and cats), ileus, urinary retention, bloat, and constipation with prolonged used

What are examples of Opiate-related agents?

*Diphenoxylate (Lomotil, Lonox)


*Loperamide (Imodium)


*Paregoric

What scheduled class is paregoric?

C-III controlled substance

Describe Loperamide

*most commonly used


*sold OTC


*synthetically made


*poorly penetrates CNS


*acceptable in most species

What are Probiotics?

*drugs that seed the GI tract with beneficial bacterial

What are some examples of Probiotics?

*Plain yogurt


*Trade names: Fortiflora, Fastrack gel, Probiocin oral gel for pets, Probiocin oral gel for ruminants

What must be done with probiotics and why?

must be kept refrigerated to maintain the viability of the bacterial culture

How is plain yogurt used to help the GI tract?

those with active cultures are often used to try to repopulate the GI flora with beneficial bacteria

Describe Metronidazole

*antibiotic effective against anaerobic bacteria


*synthetically made


*drug of choice for k-9 diarrhea


*antibiotic, antiprotozoal

What is a laxative?

medicine that loosens the bowel contents and encourages evacuation of stool

What are the 4 laxative categories?

*Osmotic


*Stimulant


*Bulk-forming


*Emollient

What are the 2 types of laxatives?

Carthartics and Purgatives

What are Carthartics?

harsher laxatives that result in a soft to watery stool and abdominal cramping

What are purgatives?

harsh carthartics, causing watery stool and abdominal cramping

Describe Osmotic laxatives

*made of salt or saline products


*pull water into the colon and increase water content in the feces


*should be limited in animals with heart failure and renal dysfunction


*Prolonged use can cause dehydration


*Not recommended in cats

What are examples of Osmotic laxatives?

*Sodium Phosphate (Fleet Enema)


*Magnesium Sulfate (Epsom salts)


*Magnesium Hydroxide (Magnalax)

What must be given with laxatives?

Free choice of water

Describe Stimulant laxatives

*irritant or contact


*increase peristalsis by irritating sensory nerve endings in the intestinal mucosa


*Rarely used in vet medicine


*SE: Severe abdominal cramping

What are some examples of stimulant laxatives?

*Bisacodyl (Dulcolax)


*Castor Oil

Describe bulk-forming laxatives

*absorb water into the intestine, increase fecal bulk, and stimulate peristalsis


*used in large animal


*free choice of water offered


*Little to no side effects

What is an example of bulk-forming laxatives?

*bran (such as pumpkin pie filling)

Describe Emollients

*stool softeners


*SE: rareW

What is an example of Emollients?

Petroleum products (solid or liquid)

Describe petroleum products

*commonly used as daily preventatives


*i.e. CatLax, Laxatone

What are antiemetics?

Drugs that control vomiting

How are most antiemetics given and why?

parentally because the patient may vomit the medication before it can be absorbed through the GI tract

How is vomiting initiated?

centrally by the direct stimulation of the vomiting center in the medulla of the brain stem or indirectly via the CRTZ

What is CRTZ?

chemoreceptor trigger zone

Where is the CRTZ located?

outside the blood-brain barrier

What does CRTZ respond to?

stimuli (drugs, toxins, etc.)

What stimulates the CRTZ ?

It results in dopamine release and stimulation of the vomiting center

What are some examples of Antiemetics?

*Phenothiazine Derivatives


*Antihistamines


*Anticholinergics


*Procainamide Derivatives


*Serotonin Receptor Antagonists (Just be aware of these)


*Neurokin (NK1) Receptor Antagonists

How do Phenothiazine Derivatives work?

By inhibiting dopamine in the CRTZ thus decreasing the stimulation to vomit

What is very important when using Antiemetics?

Keeping the animal hydrated

Why is hydration important when using Phenothiazine Derivatines?

because they cause vasodilation and hypotension

What are 4 examples of Phenothiazine Derivatives?

*Acepromazine


*Chlorpromazine


*Prochlorperzine


*Perphenazine

Describe Acepromazine

*most common


*sedative, tranquilizer, antiemetic

How do antihistamines work as antiemetics?

*used to control control vomiting in small animals when the vomiting is due to motion sickness, vaccine reactions, or inner ear problems


*block input from the vestibular system to the CRTZ

What is the antihistamines used as antiemetics?

*diphenhydramine

Describe diphenhydramine

*Benadryl


*Most commonly used


*respiratory issues, antiemetic, anti-inflammatory, pain reducer

Describe anticholinergics as antiemetics

they decrease intestinal motility and secretions and decrease gastric emptying which may decrease the tendency to vomit

Anticholinergics should not be used in what kind of animals?

animals with glaucoma or polyuric obstruction

Some Anticholinergics that help with antiemetic

Bronchodilators and antidotes for organophosphate toxicity

What are examples of antiemetic anticholinergics?

*Atropine


*Aminopentamide


*Propantheline

How do procainamide derivatives work?

centrally and peripherally

Describe centrally acting procainamide derivatives

they block the CRTZ (as a dopamine antagonist)

Describe peripherally acting procainamide derivatives

they speed gastric emptying, strengthening the cardiac sphincter tone (decreasing gastroesophageal reflux), and increase the force of gastric contractions

Procainamide derivatives are not recommended in animals with what?

GI obstructions, GI perforation, or hemorrhage

What is an example of a procrainamide derivative?

Metoclopramide (Reglan)

Describe Metoclopramide (Reglan)

*widely used in human medicine to control vomiting associated with cancer


*rapid absorption and secretion when given injectably


*limited influence on GI secretions


*Short half-life


*oral or parental


*Most effective when given by infusion pump


*contraindicated in animals with a gastrointestinal obstruction or seizure disorder

What are side effects of Metoclopramide (Regan)?

CNS disorders and constipation

Neurokinin (NK1) Receptor Antagonists example

Maropitant Citrate (Cerenia)

Describe Cerenia

*used to prevent acute vomiting and motion sickness


*Oral or SQ


*shouldn't give SQ more than 5 days in a row

What are side effects of Cerenia?

pain at injection site

What are emetics?

drugs that induce vomiting

When are emetics used?

in treatment of poisonings and overdoses

When should emetics not be used?

to induce vomiting if caustic substances are ingested such as ammonia, bleach, etc. Instead check with poison control

How emetics work?

Centrally or peripherally

Describe centrally acting emetics

Working on the CRTZ

Describe peripherally acting emetics

working on receptors locally

What are examples of central acting emetics?

Xylaxine and apomorphine

Describe Apomorphine

*Poorly absorbed orally


*instead give topically in conjunctival sac


*drug of choice for dogs

How long does Apomorphine take to work when given parentally?

within 5-10 minutes

How long does Apomorphine take to work when given subconjunctivally (topically)?

within 10-20minutes

What are the side effects of Apomorphine?

protracted vomiting, CNS depression, and restlessness

Describe Xylaxine

*induces vomiting in cats as a side effect of its use as a sedative


*drug of choice for cats


*takes 3-5 minutes when given IM in cats

What are examples of peripheral acting emetics?

*ipecac syrup


*home remedies

Describe Ipecac syrup

*causes irritation to the gastric mucosa and centrally stimulate the CRTZ


*contents of stomach and small intestine are evacuated within 10-30 minutes

What are some home remedies used to induce vomiting?

hydrogen peroxide, salt and water, mustard and water, and salt followed by food

What are antiulcer drugs?

drugs that help prevent the formation of ulcers

What are the 5 categories of antiulcers?

*Antacids


*Histamine-2 receptors


*Mucosal protective drugs


*Prostaglandin Analogs


*Proton Pump Inhibitors

What are antacids?

substances that promote ulcer healing by neutralizing HCl and reducing pepsin activity

What are the 2 types of antacids?

systemic and nonsystemic

What are systemic antacids?

Those absorbed into the blood

What are nonsystemic antacids?

Those that remain primarily in the GI tract

What are examples of systemic antacids?

*sodium bicarbonate


*calcium carbonate

What can sodium bicarbonate cause?

Sodium excess and water retention therefore it isn't frequently used in veterinary technology

What are examples of nonsystemic antacids?

alkaline salts of aluminum (aluminum hydroxide) and magnesium (magnesium hydroxide)

Describe Histamine-2 (H2) receptor antagonists

*prevent acid reflux thus reducing gastric acid secretion

How do mucosal protective drugs work?

They bind to the surface of ulcers

What are the side effects of mucosal protective drugs?

Constipation

Describe Prostaglandin Analogs

suppress gastric secretions and increase mucus production in GI tract


*Pregnant women should use caution due to prostaglandin effects

Describe Proton Pump Inhibitors

*drugs that bind irreversibly at secretory surface of partial cell to enzyme

What do proton pump inhibitors inhibit?

hydrogen ion transport into the stomach so the cell cannot secrete HCl

When HCl is blocked by proton pump inhibitors, what happens?

acid production is decreased which allows the stomach and esophagus to heal

What is an example of a proton pump inhibitor?

Omeprazole

Describe Omeprazole

*Prilosec


*used primarily in horses and foals more than 4 weeks of age


*used in combination with long term inseds like Bute

What are antifoaming drugs?

drugs that reduce or prevent formation of foamW

What are 2 examples of antifoaming drugs?

Poloxalene and Polymerized methyl

Describe Poloxalene and Polymerized methyl

*both common in large animal


*usually has "bloat" in Trade names


*Trade name examples: Bloat Guard, Bloat-Pac, etc.

What structures make up the urinary system?

paired kidneys, paired ureters, a single urinary bladder, and a single urethra

What are the functional units of the kidney?

Nephrons

What do nephrons consist of?

Loop of Henle, Glomerulus, Bowman's Capsule, proximal convoluted tubule, distal convoluted tubule, collecting duct

What are the main responsibilities of the urinary system?

*remove from the body waste products produced during metabolism


*maintain homeostasis

What are Diuretics?

drugs that increase the volume of urine excreted by the kidneys and thus promote the release of water from the tissues

What are some drug groups listed as Diuretics?

*Thiazides


*Loop Diuretics


*Potassium-Sparing Diuretics


*Carbonic Anhydrase Inhibitors


*Osmotic Diuretics

Describe Thiazides

*act on distal convoluted tubules


*long-term use causes excessive potassium secretion


*longer duration than Loop Diuretics


*Given IM, IV, and orally

What do Thiazides most commonly treat?

edema associated with congestive heart failure

What are side effects of Thiazides?

hypokalemia and cardiac dysfunction

What are some examples of Thiazides?

*Hydrochlorothiazide


*Chlorothiazide


*Hydroflumethiazide


*Bendroflumethiazide

Describe Loop Diuretics

*influence sodium-reabsorption in the loop of Henle


*inhibit tubular sodium-absorption


*potent and effective drugs that block absorption of chloride, potassium, calcium, hydrogen, magnesium, and bicarbonate


*potassium supplement recommended

What are the main side effects of Loop Diuretics?

electrolyte imbalances, especially hypokalemia, which can lead to cardiac arrythmia

What are 2 examples of Loop Diuretics?

Ethacrynic acid (Edecrin)


Furosemide (Lasix)

Describe Ethacrynic Acid

*rarely used due to popularity of Lasix

Describe Lasix (Furosemide)

*most commonly used


*inexpensive


*found everywhere (clinics)

What does Furosemide treat in small animal practice?

congestive heart failure, pulmonary edema, and hypertension

What does Furosemide treat in large animal practice?

udder edema in dairy cattle and control respiratory hemorrhaging (often seen as nosebleed) in racing horses

Describe Potassium-Sparing Diuretics

*weaker diuretics


*act on distal convoluted tubules


*anti-hypertensive effects


*preserve Potassium


*more common in cats than dogs because cats are more sensitive to hypokalemia


*more expensive


*Potassium is reabsorbed and sodium is excreted

What are examples of potassium-Sparing diuretics?

*Spironolactone


*Triamterene


*Amiloride

What is the main side effect of Potassium-Sparing Diuretics?

Hyperkalemia

What are examples of Carbonic Anhydrase Inhibitors?

*Acetazolamide


*Dichlorphenamide

Describe Carbonic Anhydrase inhibitors

*block action of the enzyme carbonic anhydrase which is used by the body to maintain acid-base balance


*mainly used to decrease intraocular pressure


*Metabolic acidosis w/ long term usage

Describe Osmotic Diuretics

*increase osmolality (concentration) of the filtrate in renal tubules


*excretion of water

What are Osmotic Diuretics used to treat?

prevent kidney failure, decrease intracranial pressure, and decrease intraocular pressure

What are examples of Osmotic Diuretics?

*Mannitol


*Glycerin

Describe Mannitol

*used to treat head trauma


*IV to promote diuresis by excreting high osmotic pressure in kidneys' tubules and limiting reabsorption

What is diuresis?

Increased excretion of urine

What is edema?

extracellular fluid accumulation

Behavior Modifying Drugs

*long term use can cause liver, kidney, and cardiovascular problems


*extra-label use required V-C-P relationship and compliance with the Animal Medicinal Drug Use Clarification Act of 1994


*usually takes 6-8 weeks to see changes

What type of drugs are used for behavior modification?

*antianxiety


*antidepressants


*hormones


*pheromones

Describe Antianxiety drugs

attempt to decrease or eliminate these behaviors: separation anxiety, excessive vocalization, whining, whimpering, and inappropriate urination

Define Anxiolitics

drugs that prevent fear or tension

What group of drugs make up Antianxiety drugs?

*antihistamines


*Benzodiazepines


*Barbiturates


*Phenothiazines

Describe Antihistamines as Antianxiety drugs

*centers on side effect of CNS depression


*used in treatment of anxiety and behaviors associated with anxiety


*Benadryl

Benzodiazepines as Antianxiety drugs

*used to relieve anxiety


*anxiolytics

Phenothiazines as Antianxiety drugs and an example

*suppress both normal and abnormal behavior


*Acepromazine

Barbiturates as Antianxiety drugs and an example

*once attributed to their ability to cause CNS depression


*phenobarbital

Antidepressant drugs

*treat various mood changes including aggression and cognitive dysfunction in animals

What are the 3 categories of antidepressants?

*Tricyclic antidepressants (TCAs)


*Monoamine Oxidase Inhibitors (MAOIs)


*Selective Serotonin Reuptake Inhibitors (SSRIs)

Tricyclic Antidepressants (TCAs)

*been used to treat separation anxiety, pruitic conditions, and compulsive disorders in animals


*amitriptyline

Monoamine Oxidase Inhibitors (MAOIs)

*the only approved drug for use in dogs in Selegiline (Anipryl)

Selective Serotonin Reuptake Inhibitors

*structurally diverse


*uses include treating depression, aggression, anxiety, phobias, and compulsive disorders


*Prozac

Hormones

*reproductive hormones: estrogens, testosterone, progestins

Drugs in the hormone category

*Diethylstibestrol (DES)


*Medroxyprogesterone acetate (Depo-Provera, Provera)


*Megestrol acetate (Ovaban, Megace)

Describe Diethylstibestrol (DES)

*second-line drug used to treat urinary incontinence

Describe Medroxyprogesterone acetate (Depo-Provera)

*treat aggression because of its calming or feminizing actions

Describe Megestrol acetate (ovaban)

*FDA approved to postpone estrus and alleviate false pregnancies in dogs


*used extra-label to treat urine spraying, anxiety, and aggression in cats

what is Alternative medicine

applies to treatments or therapies that are outside accepted conventional medicine

What is complementary medicine

implies that these therapies can be used with or in addition to conventional treatment

Describe herbal infusions

*do not require FDA approval because considered food

What are some examples of alternative and complementary medicines?

*acupuncture


*chiropractic


*physical therapy


*homeopathy


*botanical medicine


*nutraceutical medicine


*holistic veterinary medicine