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28 Cards in this Set
- Front
- Back
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Vasculitides; summary
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Temporal Arterities
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Cranial arteries; throbbing headache, tender, firm temporal arteries; visual disturbances; polymyalgia rheumatia and facial pain Associated with HLA-DR4
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Note segmental granulomatous vasculitis; multinucleated giant cells and fragmentation of the internal elastic lamina; intimal fibrosis with lumenal narrowing
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Takayasu Arteritis
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Affects young and middle aged women; affects aortic arch and great vessels; narrowing of the orifices of the major arterial branches; loss of pulse in the upper extremities
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Takayasu arteritis; marked intimal thickening with minimal residual lumen
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Polyarteritis Nodosa
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Systemic vasculitis - any organ except lung
Segmental necrotizing vasculitis, acute lesions show fibrinoid necrosis correlated w HbsAg and P=ANC |
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Wegener Granulomatosis
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Necrotizing vasculitis that tends to involve the nose, sinuses, lungs and kidney
c-ANCA is typical for WG |
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Churg-Strauss Syndrome
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Variant of polyarteritis nodosa with associated bronchial asthma, granuloma formation, and eosinophilia
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Buerger Disease (Thromboangitis Obliterans)
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Neutrophilic vasculitis that tends to involve the extremities (potentially causing gangrene) of young men who smoke heavily (cold fingers/tose)
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Smoker w cold fingers/toes
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Buerger Disease
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Blindness + loss of pulse in upper extremities
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Takayasu Arteritis
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Headache, facial pain and visual disturbances
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Temporal Arterities
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Renal, visceral artery involvement sparing pulmonary arteries
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Polyarteritis Nodosa (PAN)
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Coronary Arteries
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Kawasaki Disease
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Aortic Arch and Great Vessels
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Takayasu Arteritis
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hemoptysis; hematuria, and proteinuria; bowel pain or bleeding; muscle pain or weakness; and palpable cutaneous purpura in middle aged caucasian
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Microscopic polyarteritis
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Middled aged w 1) asthma; 2) eosinophilia [>10% on differential WBC count]; 3) mononeuropathy; 4) transient pulmonary infiltrates on chest X-rays; 5) paranasal sinus abnormalities; and 6) biopsy containing a blood vessel with extravascular eosinophils.
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Churg-Strauss Syndrome
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<35 yr, superficial nodular phlebitis, cold sensitivity of the Raynaud type (see below) in the hands, and pain in the instep of the foot induced by exercise (so-called instep claudication). severe pain, even at rest, related undoubtedly to the neural involvement. Chronic ulcerations of the toes, feet, or fingers may appear, which can be followed in time by frank gangrene.
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Thromboangiitis Obliterans (Buerger disease)
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40-50 yr, females, persistent pneumonitis with bilateral nodular and cavitary infiltrates (95%), chronic sinusitis (90%), mucosal ulcerations of the nasopharynx (75%), and evidence of renal disease (80%). Other features include rashes, muscle pains, articular involvement, mononeuritis or polyneuritis, and fever. Left untreated, the disease is usually rapidly fatal; 80% of patients die within 1 year.
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Wegeners Granulomatosis
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15-25 yo, GU (hematuria, albuminuria, hypertension); GI (abdominal pain, malena); Neuromuscular (myalgia, peripheral neuropathy); fever, weight loss
Associated with Hepatitis B |
Polyarteritis Nodosa (PAN)
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<50 yo asian woman, Ocular disturbances, neurologic deficits, attenuated upper extremities pulses, hypertension, aortic insufficiency
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Takayasu Arteritis
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>50y, US/Europe; headache, facial pain, polymyalgia rheumatica (flu like symptoms, myalgia, arthralgia, fever)
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Giant-Cell (temporal)
Arteritis |
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c-ANCA
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Wegener's Granulomatosis
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p-ANCA
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Microscopic Polyangitis
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What artery supplies the inferior leads (II, III, aVF)
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Right coronary
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What artery supplies the septal leads
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LAD
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What artery supplies the lateral leads (I, aVL, V5, V6)
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supplied by circumflex artery
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Anterior leads (V2, V3, V4) supplied by LAD
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LAD
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