Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
diffusion rate |
proportional to conc gradient, hydrophobicity and size
higher the hydrophobicity- more lipid soluble- faster it moves |
|
|
ATP powered pumps |
Na/K ATPase both against conc gradient |
|
|
ion channels |
go down conc gradient and/or membrane potential very selective dont need to change conformation like transporters and ATP |
|
|
transporters |
uniporter- only down conc - GLUT
co sym- one against and one with- same direction anti- one against and one with- oppo direction |
|
|
difference of uniporter to simple diffusion |
uniport- faster, never goes in phobic core- doesnt matter about partition coef
|
|
|
glut1 vs 2 |
GLUT1- Km is lower, 1.5mM 2 of liver cells- 20mM- store excess glucose as glycogen, cells make insulin so dont want low Km then wont stop making insulin
|
|
|
GLUT4 |
fat and muscle cells respond to insulin and uptake glucose defect= type 2 diabetes |
|
|
GLUT5 |
Km for fructose intestinal epithelial cells |
|
|
Na/K ATPase |
mtaintains intracell Na and K tetramer of alpha2beta3 glycosylate B not DIRECTLY involved in pumping |
|
|
ion channel |
membrane act like capacitor- have charge build up |
|
|
K channel |
exclude Na backbone of carbonyl oxygen- Gly-Tyr-Gly
lose 8 water but gain 8 carbonyl O low activation energy to strip off |
|
|
2Na/ 1 glucose |
14 a-helices both N & C terminal in the cytosol |
|
|
2Na/ 1 leucine symport |
aa that binds to L and 2 Na
one Na binds to carboxyl of leucine |
|
|
anion antiporter |
transport CO2 by RBC CO2 to HCO3- when RBC relesae Oxygen induces conformational change
HISTIDINE- binds to proton to make OH that binds with CO2 so HCO3 can go out while Cl comes in
|
|
|
how to rehydrate |
cant just drink water because it is being secreted out in diarrhea need sugar and salt- increase the transport and increase the osmotic flow of water into the blood from the lumen |
