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12 Cards in this Set
- Front
- Back
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32 yo m in ER with onset of severe fatigue, exertional dyspnea and fever. Cytogenetic studies demonstrate 15;17 chromosomal translocation.
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Acute Myelongenous Lekemia; failure of immature myeloid precursors (myeloblasts) to differentiate into mature granulocytes; translocation of gene for retinoic acid receptor alpha from chromsome 17 to chromsome 15 leads to formation of fusion gene PML/RAR; this gene inhibits differentiation of myeloblasts and triggers development of acute promyelocytic leukemia
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CD surface marker for the monocyte-macrophage cell lineage
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CD14
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CD surface marker for T cells
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CD4, CD7, CD8
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CD surface marker for B cells
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CD20
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5 yo w/ reccurent fatty diarrhea that does not respond to short term antibiotic therapy. Giardia infection suspected; Production of what is likely impaired in this patient?
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IgA production; usually IgA helps clear Giardia infections but a pt deficient is prone to chronic diardiasis;
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Blood smear with myeloblasts and auer rods. What is the chromosmal abnormality likely present?
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t(15;17); acute myelongeous leukemia
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Translocation for burkitt lymphoma
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t(8;14); c-myc protoconcogene; translocation next to Ig heavy chain; this placement increases production of the oncogene due to the frequencyw ith which the Ig gene is transcribed
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Translocation for chronic myelongeous leukemia
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t(9:22); bcr-abl philaelphia chromsome; constitutive tyrosine kinase activity
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Translocation for mantle cell lymphoma
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t(11:14); B cell malignancy due to activation of cyclin D genes
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Deletion in chronic lymphocytic leukemia
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13q
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23 yo with history of ulcerative colitis. Two weeks after a flare up biopsy reveals markedly decreased inflammation; what is the prototype cytokine to contribute to this change
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IL-10, also TGF-Beta
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Caucasian newborn with facial dysmorphia and cleft palate is found to have a deletion involving the long arm of chromosome 22. These findings are most consistent with what syndrome
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DiGeorge Syndrome
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