Unit 10 - 1 Pharmacology

Front 1

actions of LH on gonads

Back 1

Ovaries: prog synthesis
Testis: test synthesis

Front 2

FSH actions on gonads

Back 2

Ovaries: prog -> estrogen
Testis: spermatogenesis if enough testosterone

Front 3

Clomiphene

Back 3

blocks estrogen receptors in hypothalamus/pituitary; estrogen can't negative feedback; increased pulsation of gnRH -> LH and FSH i.e. hyperstimulates ovaries and induced ovulation

Front 4

Risk factor for ovarian hyperstimulation syndrome (which is kind of what clomiphene induces)

Back 4

polycystic ovairan syndrome

Front 5

when clomiphene fails...

Back 5

to induce ovulation: excess gonadotropins might counteract the antiestrogenic effects of clomiphene on the ripening follicles and stabilize the postgestational phase post ovulation

effective for inducing ovulation but not achieve pregnancy: might induce ovulation w a better chance of pregnancy

Front 6

best drug for anovulation

Back 6

clomiphene (estrogen antagonist in hypo/pit)

Front 7

drugs to tx hyperprolactienmia

Back 7

bromocriptine (inhibits prolactin which inhibits menstrual cycle in breastfeeding women)

Front 8

tx infertility due to hypothyroidism

Back 8

thyroxine; restores normal menstrual function and enhances fertility

elevated TSH can also provoke secondary hyperprolactinemia that will resolve w thyroxine (no bromocriptine needed)

Front 9

name for recominant FSH

Back 9

purified menotropin

Front 10

name for recombinant LH

Back 10

chorionic gonadotropin

Front 11

syntheis progesterone

Back 11

synthetic progestin