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23 Cards in this Set
- Front
- Back
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Essential amino Acids |
AA's that must be introduced through the diet |
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Non essential amino Acids |
AA's that don't to be introduced through diet |
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Glutogentic AA's |
Produce substrate for glucose when canabolized |
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Ketogeic AA's |
Produce Acetyl CoA or Acetoacetate when canabolized |
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Pyridoxal Phosphate (PLP or B6)
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transanimation and transulfuration of AA's |
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Folate |
Carbon Donor
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Cobalamin (b12) |
Conversions of: - Homocystine to Methionine - Add Methyl - Methylmanyl CoA to Succinyl CoA - Rearange mollecule - Folate Cycle |
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Tetrahydrobiperin (BH4) |
Used to convert: - Phenylalanine to Tyrosine - Tryptophan to seratonin - Tyrosine to dopamine |
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Strictly ketogenic amino Acids - Intermediate |
Lysine Leucine Acetyl CoA |
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Autozomal
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22 pairs of genes not sex genes
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X or Y linkes |
1 pair of genes sex genes |
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Wild type allele |
Most likely to be seen in nature Designated by (+) |
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how folate and SAM work together |
Folate methylates B12 B12 Methylates methionine Methionine becomes SAM SAM converts products |
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Maple Syrup Disease |
After branched chain amino acids are demainated there is a breakdown in the decarboxylation of the chain |
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Branched chain amino acids |
Leucine, Isoleucine, Valine |
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Thyamine |
Cofactor required for branched chain amino acids
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Cofactor required for Alpa keto acid dehydrogenase |
Thyamine |
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Causes of phenylketonourea |
- Deficiency in phenylalanine hydrogenase - Lack of Folate |
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Phenylalaine hydrogenase |
Converts phenylalaine to tyrosine |
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homocysene, Cysteine, Methionine cycle |
homocysteine can 1. Be methylated by folate to methionine by methionine synthase with b12 as cofactor 2. Trassulfurated by by cystathione beta synthase to cystene with b6 cofactor |
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cystathione beta synthase |
Transulfuration of homocystene to cystene - Requires B6 |
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Methotrexate |
inhibits reconstitution of folate |
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5-florouracil |
unhibits enzyme that converts dUMP to dTDP |
