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103 Cards in this Set
- Front
- Back
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What is the Brand name of Mivacurium?
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Mivacron
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How is Mivacurium typically supplied (concentration)?
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2 mg/ml
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The usual dose of Mivacurium is?
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Intubating dose 0.15-0.25 mg/kg
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What is the time to onset of Mivacurium?
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Time to intubation 1.5-2 minutes
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What is the time to peak of Mivacurium?
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1-3 minutes
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What is the duration of Mivacurium?
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12-20 minutes
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How is Mivacurium metabolized?
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plasma cholinesterase
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What receptors does Mivacurium act on?
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Binds to postsynaptic nicotinic Acetylcholine receptors and competitvely inhibits action of acetylcholine
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What drug class is Mivacurium in?
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non-depolarizing muscle relaxant
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What is the mechanism of action of Mivacurium?
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Binds to postsynaptic nicotinic Acetylcholine receptors and competitvely inhibits action of acetylcholine
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What patients would you not give Mivacurium to?
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Plasma cholinesterase deficient; reactive airway disease (b/c of histamine) Stoelting and Hiller; burn injury (burns decrease plasma cholinesterase activity - Stoelting and Hiller)
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Maintenace dose of Mivacurium?
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0.01-0.1 mg/kg
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Histamine release with Mivacurium?
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Yes (slight)
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What is the Brand name of Atracurium?
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Tracrium
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How is Atracurium typically supplied (concentration)?
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No longer available in US
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The usual dose of Atracurium is?
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0.5 mg/kg over 30-60 sec
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What is the time to onset of Atracurium?
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2-3 min
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What is the time to peak of Atracurium?
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3-5 min
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What is the duration of Atracurium?
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30-45 min
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How is Atracurium metabolized?
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Ester Hydrolysis, Hoffman Elimination
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What receptors does Atracurium act on?
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Binds to postsynaptic nicotinic Acetylcholine receptors and competitvely inhibits action of acetylcholine
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What drug class is Atracurium in?
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non-depolarizing muscle relaxant
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What is the mechanism of action of Atracurium?
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Binds to postsynaptic nicotinic Acetylcholine receptors and competitvely inhibits action of acetylcholine
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What is the Brand name of Cisatracurium?
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Nimbex
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How is Cisatracurium typically supplied (concentration)?
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2mg/ml
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The usual dose of Cisatracurium is?
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0.15-0.2mg/kg (ED95=0.05mg/kg)
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What is the time to onset of Cisatracurium?
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2-3 min
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What is the time to peak of Cisatracurium?
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2-3 min
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What is the duration of Cisatracurium?
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40-75 min
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How is Cisatracurium metabolized?
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Hoffman elimination (and possibly ester hydrolysis, Evers)
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What receptors does Cisatracurium act on?
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Binds to postsynaptic nicotinic Acetylcholine receptors and competitvely inhibits action of acetylcholine
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What drug class is Cisatracurium in?
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Intermediate acting non-depolarizing muscle blockers
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What is the mechanism of action of Cisatracurium?
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Binds to postsynaptic nicotinic Acetylcholine receptors and competitvely inhibits action of acetylcholine
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What patients would you not give Cisatracurium to?
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No significant contraindications but hypothermia and acidosis will prolong Cisatracurium's action
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What are the storage considerations for Cisatracurium?
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Must be refrigerated and used within 21 days after removal from refrigeration
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Drug-drug interactions for Cisatracurium?
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Will precipitate if introduced into same line as alkaline drugs (eg: thiopental)
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What is the Brand name of Succinylcholline?
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Anectine
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How is Succinylcholline typically supplied (concentration)?
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20 mg/mL
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The usual dose of Succinylcholline is?
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0.7 - 1.0 mg/kg intubation, 20mg for laryngospasm
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What is the time to onset of Succinylcholline?
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30-60 sec
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What is the time to peak of Succinylcholline?
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1 minute
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What is the duration of Succinylcholline?
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5 minutes
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How is Succinylcholline metabolized?
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plasma pseudocholinesterase
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What receptors does Succinylcholline act on?
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nicotinic cholinergic receptors
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What drug class is Succinylcholline in?
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Depolarizing neuromuscular relaxant
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What is the mechanism of action of Succinylcholline?
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Binds to both alpha subunits of cholinergic receptors, producing depolarization resulting in flaccid paralysis.
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What patients would you not give Succinylcholline to?
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High K+, Hx of MH, 48 -72 hrs after Spinal cord injury
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The dose of Succinylcholline for laryngospasm?
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0.15-0.3 mg/kg (10-20 mg)
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What is the Brand name of Vecuronium?
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Norcuron
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How is Vecuronium typically supplied (concentration)?
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1-2mg/mL
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The usual dose of Vecuronium is?
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0.08-0.1 mg/kg
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What is the time to onset of Vecuronium?
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2-3 min
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What is the time to peak of Vecuronium?
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3-5 min
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What is the duration of Vecuronium?
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30-45 min
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How is Vecuronium metabolized?
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Hepatic
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What receptors does Vecuronium act on?
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nicotinic cholinergic receptors
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What drug class is Vecuronium in?
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Non-depolarizing neuromuscular relaxant
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What is the mechanism of action of Vecuronium?
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Competitively binds to Alpha subunit(s) of cholinergic receptor at motor end plate. Preventing Na+ and Ca++ from entering and K+ from exiting
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What patients would you not give Vecuronium to?
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those with hepatic dysfunction or extrahepatic biliary obstruction due to prolonged duration
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What is the Brand name of Pancuronium?
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Pavulon
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How is Pancuronium typically supplied (concentration)?
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1mg/mL, 2mg/mL
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The usual dose of Pancuronium is?
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Intubating- 0.04 - 0.1 mg/kg, 0.01-0.05 mg/kg maintainece
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What is the time to onset of Pancuronium?
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1-3 min
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What is the time to peak of Pancuronium?
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3-5 minutes
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What is the duration of Pancuronium?
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60-90 minutes
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How is Pancuronium metabolized?
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Hepatic (deacetylated), Excretion is 40% renal, 10% bile
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What receptors does Pancuronium act on?
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It is Bisquaternary, acts on nicotinic choliergic receptor
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What drug class is Pancuronium in?
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Nondepolarizing muscle relaxants
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What is the mechanism of action of Pancuronium?
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Competitively binds to Alpha subunit(s) of cholinergic receptor at motor end plate. Preventing Na+ and Ca++ from entering and K+ from exiting
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What patients would you not give Pancuronium to?
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Pt in whom an increased heart rate would be particularly detrimental (coronary artery disease, IHSS); Renal patients may have prolonged neuromuscular blockade
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What is the Brand name of Pipecuronium?
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Arduan
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How is Pipecuronium typically supplied (concentration)?
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10mg powder
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The usual dose of Pipecuronium is?
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0.07-0.085 mg/kg
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What is the time to onset of Pipecuronium?
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2 min
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What is the time to peak of Pipecuronium?
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3-5 minutes
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What is the duration of Pipecuronium?
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45-120 min
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How is Pipecuronium metabolized?
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Renal
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What receptors does Pipecuronium act on?
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cholinergic receptors at the motor end plate
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What drug class is Pipecuronium in?
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long acting nondepolarizing neuromuscular blocking agent
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What is the mechanism of action of Pipecuronium?
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competitive antagonist at the cholinergic receptors of the motor end plate
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What patients would you not give Pipecuronium to?
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enhanced neuromuscular blockade in pts with myasthenia gravis or inadequate adrenocortical function
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Does Pipecuronium release histamine?
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No
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What is the Brand name of Rocuronium?
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Zemuron
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How is Rocuronium typically supplied (concentration)?
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10mg/ml
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The usual dose for intubation with Rocuronium is?
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0.6-1.2mg/mg
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What is the time to onset of Rocuronium?
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60-90 sec
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What is the time to peak of Rocuronium?
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1-3 min
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What is the duration of Rocuronium?
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30-60 (150) min
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How is Rocuronium metabolized?
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Hepatic; It is excreted 30% Renal, 70% Biliary
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What receptors does Rocuronium act on?
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nicotinic cholinergic receptor
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What drug class is Rocuronium in?
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Non-depolarizing neuromuscular relaxant
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What is the mechanism of action of Rocuronium?
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Competitively binds to Alpha subunit(s) of cholinergic receptor at motor end plate. Preventing Na+ and Ca++ from entering and K+ from exiting
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What is the Brand name of Doxacurium?
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Nuromax
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How is Doxacurium typically supplied (concentration)?
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1 mg/ml
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The usual dose of Doxacurium is?
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0.05-.08mg/kg
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What is the time to onset of Doxacurium?
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2 mins
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What is the time to peak of Doxacurium?
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3-9 mins
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What is the duration of Doxacurium?
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30-60 mins
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How is Doxacurium metabolized?
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Minimal metabolism Excreted Renally
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What receptors does Doxacurium act on?
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acetylcholine receptors of the nicotinic type
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What drug class is Doxacurium in?
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non-depolarizing muscle relaxant
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What is the mechanism of action of Doxacurium?
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Binds to postsynaptic nicotinic Acetylcholine receptors and competitvely inhibits action of acetylcholine
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What is the maintenance dose of Rocuronium?
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0.15 mg/kg
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