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15 Cards in this Set
- Front
- Back
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What problems were associated with early inhalation anesthetics?
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Unstable
Flammable Prolonged effect |
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What process reduces flammability in volatile anesthetics?
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Halogenation
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What process reduces solubility of volatile anesthetics?
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Fluorination
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What process adds stability to valatile anesthetics?
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Trifluorocarbon group
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What effect do alkanes have on volatile anesthetics?
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Precipitate arrhythmias
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Define MAC
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Minimum alveolar concentration: the amount of VA under which 50% of people will not move under surgical stimulation.
Reflects potency |
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Define BGC
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Blood :Gas Partition Coefficient: A numerical value indicating the relative affinity of a gas for the blood compaired to air.
Reflects solubility and therefore speed of onset. |
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Is BGC directly or inversely related to speed of onset?
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Inversely-the higher the BGC, the slower the speed of onset.
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How is BGC related to MAC?
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The higher the BGC, the the lower the MAC.
More soluble =more potent |
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Would you expect the MAC of a 1)pediatric patient
2)elderly patient to be higher or lower than an adult? |
1)peds- higher
2)elderly-lower |
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What is the Critical Volume Hypothesis?
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Postulates that anesthetic molecules combine with lipids in the cell membrane and "disorganize " it, resulting in failure of synaptic transmission.
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What does Fick's laws state?
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Describes the RATE of DIFFUSION as a function of the CONCENTRATION GRADIENT and the PROPERTIES of the MEDIUM through which they diffuse.
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What is the Meyer-Overton Principle?
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There exists a close correlation of anesthetic potency and lipid solubility.
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What is the Meyer Overton Hypothesis?
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Anesthetic molecules dissolve into membrane lipids and interact at hydrophobic sites.
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What is Henry's Law?
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Describes the relationship between the partial pressure of a gas above a solution and the concentration of the gas in it.
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