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16 Cards in this Set
- Front
- Back
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Amphotericin mech
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Binds ergosterol
Punches holes in cell membrane Disrupts membrane Leakage |
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Nystatin mech
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Binds ergosterol
Punches holes in cell membrane Disrupts membrane Leakage |
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Flucytosine mech
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Converted to active form flurouracil in the cell
Disrupts DNA and protein synthesis |
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Fluconazole mech
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Inh lanosterol demethylase, an enzyme in ergosterol synthesis
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Miconazole
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Inh lanosterol demethylase, an enzyme in ergosterol synthesis
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Terbafine mech
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Inh squalene epoxidase enyzme in ergosterol synthesis
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Griseofulvin mech
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Binds polymerized microtubules
Disrupts spindle Blocks replication |
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Caspofungin mech
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Competitively inh fungal cell wall synthesis
Causes cells to lyse |
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Amphotericin B side effects
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Fever/ chills
Dose-limiting renal toxicity Hypotension Hypokalemia Normocytic anemia Thrombophlebitis |
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Nystatin side effects
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Few topically
Highly toxic if given orally |
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Flucytosine AE
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Decreased bone marrow function- leukopenia, thrombocytopenia
N/V/D |
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Fluconazole AE
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P450 inh
Inh human ergosterol synthesis Lots of drug reactions N/V Rash |
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Miconazole AE
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P450 inhibitor
Inh human sterol synthesis Local burning, irritation, itching |
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Terbinafine AE
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Allergic rxn if given orally
Can't be used if hepatic impairment Adjust dose if renal impairment |
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Griseofulvin AE
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P450 inducer
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Caspofungin
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Phlebitis and histamine reaction at injection site.
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