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17 Cards in this Set
- Front
- Back
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Henderson-Hasselbach Revised
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pH - pKa = log(base/acid)
Weak base: Base = 1 Weak acid: Acid = 1 |
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1st-Order Elimination
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Slope = -ke on ln(x) vs T curve
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Half-life
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t0.5 = 0.7/ke
t0.5 = 0.7Vd/CL |
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Volume of distribution
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Vd = Drug Amount / Concentration
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Therapeutic Index
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TD50/ED50
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Certain Safety Factor
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TD1/ED99
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Standard Safety Margin
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(TD1-ED99)/ED99 * 100%
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Clearance
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CL = ke/C
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Elimination Constant
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ke = CL/Vd
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Renal Clearance
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CLr = CuVu/Cp
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Normal GFR
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130 ml/min
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Normal RPF
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650 ml/min
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Normal RBF
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1300 ml/min
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Normal CO
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4200 ml/min
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Steady-State Concentration w/Infusion
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Ro = CL * Css
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Maintenance Dose
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MD = CL * Css * tau
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Loading Dose
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LD = Vd * Css
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