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55 Cards in this Set
- Front
- Back
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Atenolol
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Class: Selective adrenergic antagonist
Specificity: β1 receptors Chemistry: No ISA, no stabilization, very hydrophilic, renal excretion, incomplete absorption from GI. Usage: HT, CHF, chronic stable angina, arrhythmia/tachycardia, post-MI, hyperthyroid, pheochromocytoma, migraine, glaucoma Note: Esp. in diabetes, COPD, Raynaud's |
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Bishydroxycoumarin
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Class: Anticoagulant
Specificity: Vitamin K epoxide reductase Chemistry: Highly plasma-protein bound at warfarin site Usage: Anticoagulation Note: Prototype drug of warfarin Note: Metabolized by CYP3 (which is induced by phenobarbital). |
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Bisoprolol
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Class: Highly selective adrenergic antagonist
Specificity: β1 receptors Chemistry: No ISA, no stabilization Usage: HT Note: Esp. in diabetes, COPD, Raynaud's |
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Botulinum toxin
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Class: Cholinergic release inhibitor
Usage: Muscle relaxant |
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Choline
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Note: Component of acetylcholine. Uptake blocked by hemicholiniums.
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Cimetidine
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Note: Reversible P450 inhibitor
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Clofibrate
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Note: CYP4 inducer
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Creatinine
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Note: Clearance of creatinine used to estimate GFR via Cockcroft-Gault equation?
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Cyclic AMP
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Note: Second messenger
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Cyclic GMP
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Note: Second messenger
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Diazepam
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Note: Has unique binding site on albumin.
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Digitoxin
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Note: Has unique binding site on albumin.
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Ephedrine
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Class: Mixed adrenergic agonist
Specificity: α, β receptors Chemistry: Non-catecholamine Usage: Decongestant, bronchospasm |
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Epinephrine
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Class: Direct adrenergic agonist
Specificity: α, β receptors Chemistry: Catecholamine Usage: Anaphylaxis, bronchospasm, allergy, cardiac arrest, prolonged local anesthesia, glaucoma (α-agonist) Duration: Minutes |
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Esmolol
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Class: Adrenergic antagonist
Specificity: β1 receptors Usage: Arrhythmia Duration: Minutes |
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GABA
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=()=
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Gentamicin
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=()=
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Glucocorticoids
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=()=
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Glutamate
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=()=
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Glycine
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=()=
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Histamine
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=()=
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Inositol phosphate
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=()=
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Insulin
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=()=
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Isoniazid
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=()=
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Isoproterenol
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Class: Direct adrenergic agonist
Specificity: β receptors Chemistry: Catecholamine Usage: Bronchospasm, cardiac arrest, heart block Duration: Minutes |
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Labetalol
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Class: Mixed adrenergic antagonist
Specificity: α1, β receptors Usage: Hypertension |
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Metaproterenol
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Class: Direct adrenergic agonist
Specificity: β2 receptors Chemistry: Inhaled catecholamine Usage: Asthma, bronchospasm Duration: Minutes |
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Methylphenidate
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=()=
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Metoprolol
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Class: Selective adrenergic antagonist
Specificity: β1 receptors Chemistry: No ISA, no stabilization, complete absorption from GI, high FPE, idiosynchratic metabolism due to CYP2D6 (~7x). Usage: HT, CHF, chronic stable angina, arrhythmia/tachycardia, post-MI, hyperthyroid, pheochromocytoma, migraine, glaucoma Note: Esp. in diabetes, COPD, Raynaud's |
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Morphine
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=()=
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Muscarine
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=()=
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Na+/K+ ATPase
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=()=
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Nicotine
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=()=
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Nitric oxide
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=()=
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Norepinephrine
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Class: Direct adrenergic agonist
Specificity: α, β1 receptors Chemistry: Catecholamine Usage: Severe hypotension in shock Duration: Minutes |
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Phenobarbital
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=()=
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Phenoxybenzamine
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Class: Irreversible adrenergic antagonist
Specificity: α receptors Chemistry: Alkylating, oral Usage: Diagnosis and surgical prep of pheochromocytoma, peripheral vascular disease, BPH Note: Inhibits NE reuptake, blocks H1, ACh, and 5HT receptors Duration: Long |
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Phentolamine
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Class: Adrenergic antagonist
Specificity: α receptors Chemistry: IV only Usage: Hypertensive crisis, pheochromocytoma, erectile dysfunction Note: Inhibits NE reuptake, stimulates histamine release, secretion of gastric acid Duration: Short, fast |
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Pindolol
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Class: Selective adrenergic antagonist with ISA
Specificity: β receptors Chemistry: Partial agonist Usage: HT, arrhythmia |
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Prazosin
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Class: Adrenergic antagonist
Specificity: α1 receptors Usage: Hypertension, BPH Duration: Twice daily |
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Primaquine
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=()=
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Propranolol
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Class: Adrenergic antagonist
Specificity: β receptors Chemistry: CNS, plasma protein binding, hepatic metabolism with significant FPE Usage: HT, CHF, chronic stable angina, arrhythmia/tachycardia, post-MI, hyperthyroidism, pheochromocytoma, migraine. |
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Pseudoephedrine
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Class: Direct adrenergic agonist
Specificity: α, β receptors Chemistry: Catecholamine Usage: Anaphylaxis, bronchospasm, allergy, cardiac arrest, prolonged local anesthesia, glaucoma (α-agonist) Duration: Minutes Note: Less bronchodilation than ephedrine |
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Rifampin
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=()=
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Ritodrine
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Class: Direct adrenergic agonist
Specificity: β2 receptors Chemistry: Catecholamine Usage: Premature labor Duration: Minutes |
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Salmeterol
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Class: Direct adrenergic agonist
Specificity: β2 receptors Chemistry: Inhaled catecholamine Usage: Asthma, bronchospasm Duration: Hours |
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Substance P
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=()=
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Succinylcholine
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=()=
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Terazosin
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Class: Adrenergic antagonist
Specificity: α1 receptors Usage: Hypertension, BPH Duration: 18 hours |
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Terbutaline
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Class: Selective adrenergic antagonist
Specificity: β1 receptors Chemistry: No ISA, no stabilization, complete absorption from GI, high FPE, idiosynchratic metabolism due to CYP2D6 (~7x). Usage: HT, CHF, chronic stable angina, arrhythmia/tachycardia, post-MI, hyperthyroid, pheochromocytoma, migraine, glaucoma Note: Esp. in diabetes, COPD, Raynaud's |
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Theophylline
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=()=
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Timolol
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Class: Adrenergic antagonist
Specificity: β receptors Chemistry: Hepatic metabolism & renal excretion Usage: Open-angle glaucoma, and similar to propranolol |
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Tyrosine kinase
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=()=
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Vitamin D
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=()=
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Warfarin
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=()=
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