Uiuc M2 2010 Fcp Scleroderma

Front 1

Patients are said to have Systemic Sclerosis (SSc) by ACR criteria:

Back 1

one major criterion,
or
2 of the 3 minor criteria

Major:Proximal scleroderma
Minor:
1)Sclerodactyly
2) Digital pitting scar
3) Interstitial change on chest x-ray

Front 2

Proximal scleroderma

features in systemic sclerosis:

Back 2

Major criterion for Sclerosis

Thick skin of fingers and hands, (or forearm, torso, face,.
Atrophic (Thin) skin of face

Front 3

Sclerodactyly

features in systemic sclerosis:

Back 3

Minor criterion for Systemic Sclerosis

early puffy fingers
Taut, thick skin of (just) fingers

Front 4

Digital pitting scar

features in systemic sclerosis:

Back 4

Minor criterion for Systemic Sclerosis

Front 5

LeRoy & Medsger have suggested two additional criteria to diagnose mild SSc:

Back 5

Raynaud’s phenomenon (plus both):
1) nailfold capillary abnormalities
and
2) SSc-specific antibodies (anti-centromere, anti-SCL-70, anti-PM-Scl, etc)

Front 6

SSc-specific antibodies

Readily available:
Not so available:

Back 6

Anti-centromere
Anti-SCL 70
Anti-PM/Scl

Anti-Th/To
Anti-RNA polymerase III
Anti-fibrillarin

Front 7

CREST

Back 7

Calcinosis cutis
Raynauds
Esophageal Dysmotility
Sclerodactyly
Telangiectasias