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40 Cards in this Set
- Front
- Back
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Syphilis-HIV connection
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Syphilis upregulates CCR5
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HPV Virus Class
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dsDNA circular non-enveloped
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HPV Strata Sequence
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Infects basalis
Replicates spinosum Matures granulosum Released corneum |
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HPV proteins
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E6 - inactivates p53 (no DNA damage apoptosis)
E7 - inactivates Rb, removing cell cycle block |
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Chlamydia org type
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G- rod, intracellular. Inactive infectious form (elementary), active non-infectious form (reticulate).
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Chlamydia systemic spread
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Asymptomatic in females
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Chlamydia immunity
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Not lasting. Re-infection results in vigorous response that causes tissue damage (scarring, infertility, etc)
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Chlamydia specials
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Trachoma (blindness), oculogenital, etc.
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Chlamydia dx
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PCR
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Chlamydia tx
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Azithromycin (+doxycycline for gonorrhea)
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Gonococcus epi
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Blacks > whites, south > north, females > males.
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Gonococcus virulence factors
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Pilus - attach to epithelium (constant/hypervariable regions)
Opa - attach to epithelium LOS - endotoxin RMP - inhibits serum bactericides IgA protease - mucus IgA Capsule - resists phagocytosis (w/o Ab) Sperm adherence - can get into vagina that way, causes PID |
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Gonococcus dx
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Culture, PCR
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Gonococcus tx
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Doxycycline (+azithromycin for chlamydia), NO penicillin.
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Treponeme tx
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Penicillin
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Trichomonas dx
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Visualization
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Trichomonoas tx
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Metronidazole both partners
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Sweat glands flora
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None - sterile!
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Sebaceous glands flora
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Aerobes - Conybacterium/propionibacterium
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Dry skin flora
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G+ S. epidermidis
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Not normal flora of skin
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S. pyogenes - needs breaks in skin to colonize, comes from pharynx
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Impetigo
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Infection of epidermis
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Erysipelas
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Infection of dermis
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Cellulitis
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Infection of fat
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Fasciitis
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Infection of fascia (necrotizing = destruction)
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Folliculitis
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Infection of hair follicle (P. acnes, S. aureus)
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Deep wound infection
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Anaerobes (clostridium)
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Burn infections
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P. aeruginosa, S. aureus
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S. aureus virulence factors
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Antiphagocytic capsule
Binds fibronectin/coats w/host protein Surface protein A - binds Fc Alpha toxin - pore-forming, kills PMNs |
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Impetigo requires this for infection
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Breaks in skin, exfoliative toxins A+B
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S. pyogenes virulence factors
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Antiphagocytic capsule
M-protein (binds Factor H more than Factor B, degrades C3b, prevents opsonization) Protein G - pus, hydrolytic enzymes, streptokinase |
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Necrotizing fasciitis
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Group A strep, M serotypes, requires breach in skin
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S. pyogenes tx
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Penicillin
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S. pyogenes syndromes
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Scarlet fever - TSS-like syndrome, grows in throat, toxins go throughout body, type IV hypersensitivity to SPEs
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B. fragilis tx
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Clindamycin
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B. fragilis dx
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Culture or fluorescent antiserum
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Pseudomonas virulence factors
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Endotoxin A (diptheria-like)
Kills phagocytes Protects from immune system (in endothelium of blood vessels) Resistant to antibiotics LPS |
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Herpes virus type
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Enveloped dsDNA
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Measles virus type
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Enveloped (-)ssRNA
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Rubella virus type
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Enveloped (+)ssRNA
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