U: Glomerular Dz - Nephritis

Front 1

What are some of the general distinctions between nephrotic syndrome and nephritic syndrome?

Back 1

Nephritis has less of the classic features like hematuria, proteinuria, edema, and MORE of the stuff suggesting a more disruptive lesion.
(RBC casts, etc.)
- note that we're really talking about glomerular nephritis, not tubular interstitial nephritis here.

Front 2

What are basement membrane nephropathies and why can they be probelmatic in terms of dx?
- example?
- chief presentaion sx?

Back 2

they can mimic the more inflammatory nephritic syndrome sx (can mimic IgA nephropathy (type of nephritis))
- Thin GBM nephropathy
- asymptomatic hematuria
--> note that while ~1/3 of asx. hematuria is caused by IgA nephropahty, most pts with IgA don't have it.

Front 3

Basement membrane nephropathies are ______ disorders caused by abnormalities in _______.

Back 3

hereditary dz caused by defects in type IV collagen.

Front 4

What is Alport's syndrome?

Back 4

type of glomerula basement membrane nephropathy that shows malformed (not thin like thin GBM) basement membrane due to defect in TIV collagen. It has a worse prog than Thin GBM.

Front 5

Linear IF staining - think waht?

paucity of glomerular IF staining?

Back 5

Anti GBM dz

immune complex dz

ANCA

Front 6

Actue glomerulo nephritis with incrased cells inluding numerous marginated and infiltrating neutrophils resulting in an acute diffuse proliferative glomerularnephrtitis. Thiank what? Most often caused by?

Back 6

acute posinfectious Glom. nephritis
strep or staph

Front 7

for post infectious (acute) nephritis, what chances should you look for on EM?

Back 7

subepithelial immune complex humplike deposits.

Front 8

If the infection manages to last for a long time --> chronic, what type of dz pattern is seen developing?

Back 8

membranoproliferative Glomerulonephritis.

Front 9

What two features are seen in membranoproliferative glomerulonephritis? Is this how IgA nephropathy always presents?

Back 9

hypercellularity and thick capillary walls.

No, it can range from histologically normal gomeruli to crescenteric/sclerosis. Just depends on when you catch it.

Front 10

What is IgA nephropathy?

Back 10

glom dz w/ IgA dominant or codominant mesangial immunoglobulin.

Front 11

What is the most common golmerulonephritis in the world? More likely in AA?
Age of presentation?

Back 11

IgA nephropathy

No, less, very uncommon.

typically middle=aged (20s-40s)

Front 12

- Episodic macroscopic hematuria
- asd. hematuria and proteinuria
- rapildly progressive glomerulonephritis
- chronic renal failure
- nephrotic syndrome
- actue renal failure with gross hematuria

all are what?

Back 12

patterns of possible clinical presentation of some of the nephritisis.

Front 13

Episodic Macroscopic hematuria w/ Sydpharyngitic glomerulonephritis is a presentation most common in which age group?
- why is the timing critical?

Back 13

children
- in IgA nephropathy, the URI/GI infection occurs around the SAME TIME as the hematuria... in post-infectious, it's a few weeks later, at least.

Front 14

Are those with IgA nephropathy presenting with asymptomatic hematuria/proteinuria at lower or higher risk of eventually progression to sclerosis when comparted with those that present with episodic gross hematuria?

Back 14

higher risk.

Front 15

Place the following in one of three categories re: presenting sx: those w/o hypocomplementemia, those with only C3 hypocomplementemia, those with both C3 and C4 hypocomplementemia:
- Henoch-Schonlein purpura
- MPGN
- ANCA-associated SVV
- IgA nephritis
- Endocartditis GN (including shunt nephrosis)
- Lupus
- Cryoglobulinemia DN
- Postinfectious GN

Back 15

none:
- Anca, IgA, Henoch

C3:
PostInf. GN
Endocarditis GN
MPGN

Both:
Lupus
Cryoglobulinemic DN

Front 16

Worldwide, what is the most common cause of Type I MPGN? Prog?

Back 16

Hep C
- maj of pts with idiopathic MPGN progress
- may improve if there is an identiable cause and that cause is tx'ed.

Front 17

hematuria
HTN
renal insufficiency
some edema
- makes you think either nephritic or nephrotic?

predominant proteinuria
edema
if it lasts, renal insufficienty
if it lasts, HTN
nephritic/nephrotic

Back 17

- nephritic
- nephrotic