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28 Cards in this Set

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Expression
Rickettsial diseases – tiny Gm- rods
Rick____sial diseases - tiny __- rods
Expression
4 types
Epidemic typhus
Brill-Zinsser disease
Endemic typhus
Scrub typhus
Expression
Epidemic typhus
occurring in war, poverty, famine
fucked up situations
Expression
Brill-Zinsser disease
reoccurrence of epidemic typhus, possibly endemic
Expression
Endemic typhus
present consistently in certain areas
hence the reason for endemic retard
Expression
Scrub typhus
areas with dense vegetation
get yo veggiesss
History
Ancient disease (Greece 400-500 BCE)
History
Problem in what circumstances?
Crowded places
Killed 20-30m people after WWI
Epidemiology
Age important?
yea. >50 have 40-60% mortality (highest)
Epidemiology
Epidemic typhus
humans sole host; vector is human body louse; crowding,
hygiene, and poverty have role; few cases in US; present in Africa, Central America, South America; cases increase during colder weather – why?
we're killing ourselves!! well not in US woohoo
Epidemiology
Endemic typhus (also called murine (mouse) typhus)
Reservoir: Vector?
Reservoir = rodents
vector = flea
Epidemiology
Scrub typhus
Reservoir? Vector?
rodents reservoir
vectors are immature mites (chiggers)
vector = itchy legs
Etiology
Causative Agent of Epidemic typhus
Rickettsia prowazekii
Rickettsia prowa_____
Transmission of Epidemic typhus
carried by body lice; lice bites skin
can infect eye or respiratory tract directly or by inhalation
Causative Agent
Endemic typhus
Rickettsia typhi
Transmission of endemic typhus
infected fleas on mice or rats inoculate
human skin; rarely through inhalation
dirty bastards
Causative Agent
Scrub Typhus
Rickettsia (Orientia) tsutsugomushi
don't get too too mushi
Transmission of Scrub Typhus
humans become
accidental hosts when chigger bites skin and inoculates with bacteria
fucking ITCHYYYYYY
Pathogenesis
Rickettsia infect:
macrophages, and grow inside other cells; also attack cells in walls of blood vessels
m__________, other cells and grow _______; also attack cells in _____ of
blood ve_______
Pathogenesis
7-10 days of what?
Intracellular latent period
interstellar domination
first Symptoms/signs:
frontal, headache, high fever, chills, muscle pain
day 15-17 symptoms/signs
rash appears, first trunk then extremities except face, palms, soles
scratch that shit yo
Severe cases outcomes
personality changes, low urine output due to renal effects, hypotension, gangrene, mortality
typhus made me skitzo bitch...and i cant peeee!! Hey honey look! I'm flyingg!!! not. dead.
Age matters with typhus?
hell yea nukka>>>>Adults are fooked
Treatment:
Rx: tetracycline or chloramphenicol
if signs are present it's challenging
tetra + cyclone - o + i
chloram phen i col
recurrance possible?
yea. Brill-Zinsser Disease
Vaccine?
yea. not approved in US but it's around
what is the best way to eradicate Typhus?
kill the vectors; best in endemic typhus
kill those fury dirty fuckers!