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28 Cards in this Set
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Expression
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Rickettsial diseases – tiny Gm- rods
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Rick____sial diseases - tiny __- rods
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Expression
4 types |
Epidemic typhus
Brill-Zinsser disease Endemic typhus Scrub typhus |
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Expression
Epidemic typhus |
occurring in war, poverty, famine
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fucked up situations
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Expression
Brill-Zinsser disease |
reoccurrence of epidemic typhus, possibly endemic
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Expression
Endemic typhus |
present consistently in certain areas
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hence the reason for endemic retard
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Expression
Scrub typhus |
areas with dense vegetation
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get yo veggiesss
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History
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Ancient disease (Greece 400-500 BCE)
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History
Problem in what circumstances? |
Crowded places
Killed 20-30m people after WWI |
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Epidemiology
Age important? |
yea. >50 have 40-60% mortality (highest)
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Epidemiology
Epidemic typhus |
humans sole host; vector is human body louse; crowding,
hygiene, and poverty have role; few cases in US; present in Africa, Central America, South America; cases increase during colder weather – why? |
we're killing ourselves!! well not in US woohoo
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Epidemiology
Endemic typhus (also called murine (mouse) typhus) Reservoir: Vector? |
Reservoir = rodents
vector = flea |
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Epidemiology
Scrub typhus Reservoir? Vector? |
rodents reservoir
vectors are immature mites (chiggers) |
vector = itchy legs
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Etiology
Causative Agent of Epidemic typhus |
Rickettsia prowazekii
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Rickettsia prowa_____
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Transmission of Epidemic typhus
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carried by body lice; lice bites skin
can infect eye or respiratory tract directly or by inhalation |
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Causative Agent
Endemic typhus |
Rickettsia typhi
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Transmission of endemic typhus
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infected fleas on mice or rats inoculate
human skin; rarely through inhalation |
dirty bastards
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Causative Agent
Scrub Typhus |
Rickettsia (Orientia) tsutsugomushi
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don't get too too mushi
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Transmission of Scrub Typhus
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humans become
accidental hosts when chigger bites skin and inoculates with bacteria |
fucking ITCHYYYYYY
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Pathogenesis
Rickettsia infect: |
macrophages, and grow inside other cells; also attack cells in walls of blood vessels
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m__________, other cells and grow _______; also attack cells in _____ of
blood ve_______ |
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Pathogenesis
7-10 days of what? |
Intracellular latent period
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interstellar domination
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first Symptoms/signs:
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frontal, headache, high fever, chills, muscle pain
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day 15-17 symptoms/signs
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rash appears, first trunk then extremities except face, palms, soles
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scratch that shit yo
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Severe cases outcomes
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personality changes, low urine output due to renal effects, hypotension, gangrene, mortality
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typhus made me skitzo bitch...and i cant peeee!! Hey honey look! I'm flyingg!!! not. dead.
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Age matters with typhus?
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hell yea nukka>>>>Adults are fooked
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Treatment:
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Rx: tetracycline or chloramphenicol
if signs are present it's challenging |
tetra + cyclone - o + i
chloram phen i col |
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recurrance possible?
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yea. Brill-Zinsser Disease
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Vaccine?
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yea. not approved in US but it's around
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what is the best way to eradicate Typhus?
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kill the vectors; best in endemic typhus
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kill those fury dirty fuckers!
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