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6 Cards in this Set
- Front
- Back
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Primary
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Myeloma (bone marrow tumour) produces a lot of immunoglobulin (single class Ig with same light chain)
Light chain forms amyloid material - AL Deposited in: heart, liver, kidneys, spleen |
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Secondary
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Cytokines are secreted in response to chronic infl. causing the liver to produce serum amyloid protein A (SAA, AA amyloid)
Common causes: RA, inf. bowel disease, osteomyelitis, renal cell carcinoma, Hodgkin's disease Deposited in: liver, spleen, kidneys |
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Senile
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Small amyloid deposits from serum prealbumin occur in the elderly
Asymptomatic but can cause enlarged waxy heart |
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Haemodialysis-associated
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B2-microglobulin is deposited in various organs in patients with chronic renal failure, treated with haemodialysis
Affects: synovium, joints, tendon sheaths |
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Hereditary
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RARE
Familial mediterranean fever, Portuguese neuropathy, Familial amyloidotic neuropathy |
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Localised
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Different types:
Localised nodular deposits Alzheimers Endocrine amyloid - from medullary carcinoma of the thyroid, islet cell pancreatic tumours, phaeochromocytomas, |
