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22 Cards in this Set
- Front
- Back
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cell cycle --- agents given in continued prolonged schedules
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specific
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cell cycle --- agents given in large, intermittent doses
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non-specific
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why intermittent tx
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so marrow/normal tissues can recover
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chemo should be given ----- w one effective regimen used initially
w/ other equally effective ------ regimens held in reserve for resistant disease |
sequentially
non-cross resistant |
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by not exposing tumor to several agents initially:
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sensitivity to some agents will be mainatined
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probability of developing resistance is directly r/t:
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# of cell divisions
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large # populations are likely to have ---- resistant cells population
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>/= 1
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in order to prevent relapse what should be done
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all effective agenst would be used up front
an all out attack will destroy the highly sensitive tumor cells and not allow resistant cells to grow back |
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pts should be dosed to either -- or ----
whichever comes first, before tx is changed |
tumor response
toxicity |
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complete elimination of all evidence of disease
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complete response
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aka complete remission
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complete response
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t/f
complete response is a cure |
f
it's a requirement of a cure |
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partial respnse is --- reduction in tumor burden, generally lasting 1 month w/ no new lesions
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>/= 50%
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overall response =
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CR + PR
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mearsurable response
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< 50% reduction
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stable disease
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no change
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increase in tumor burden during tx
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progressive disease
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cured =
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when alive w/ NED for several years
exact # years depend on type of Ca |
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2ndary goal
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prolong ca
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primary goal
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cure
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if unable to cure or prolong survival what occurs
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palliation to reduce s/s
increase QOL |
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-- correlates well w/ cardiac output, which reflects bl flow to liver and kidney
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BSA
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