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37 Cards in this Set
- Front
- Back
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Define: vasculitide
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1) the presence of leukocytes in the vessel wall with reactive damage to mural structures
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What are the three different pathogenic models for the vasculitis disease process?
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"1) distribution of antigen determines pattern of involvement
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Whata rehte two most common mechanisms of vasculitis?
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"1) local or systemic infection
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What are the different immunlogic mechanisms for the pethogenesis of vasculitides
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"- immune complex deposition
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Describe the development of the ANCA-associated vasculitis
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"1) proinflammatory cytokines and chemokines are released
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What are the two types of ANCA?
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"- P-ANCA: antimyeloperoxidase; p = perinuclear staining
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What are the systemic vasculitides classifications based on?
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"1) size of involved blood vessels
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What disease process should be considered in a Pt w/ systemic sx in combination with evidence of single and/or multiorgan dysfxn
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1) vasculitis
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What are common SiSx of vasculitis?
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"- fatigue
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What are the major large vessel vasculitis?
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"- Giant cell (temporal arteritis)
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What are the medium-sized vessel vasculitis?
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"1) polyarteritis nodosa
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What are the small vessel vasculitis?
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"1) Wegener granulomatosis
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Describe Giant cell (temporal) arteritis
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"- Granulomatous arteritis of aorta and major branches
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Describe Takayasu arteritis
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"- granulomatous inflammation of aorta and its major branches
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Describe polyarteritis nodosa
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"- necrotizing inflammation of medium-sized or small arteries without glomerulonephritis or vasculitis in arterioles, cappillaries, or venules
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Describe Kawasaki dz
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"- arteritis involving large, medium, and small arteries
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Describe Wegener granulomatosis
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"- granulomatous inflammation involving the respiratory tract
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"
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"- eosinophil-rich and granulomatous inflammation
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Describe microscopic polyangiitis
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"- necrotizing vascultiis w/ few/no immune deposits
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Describe Henoch-Schonlein purpura
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"- vasculitis w/ IgA dominant immune deposits
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Describe essential cryoglobulinemic vasculitis
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"- vasculitis w/ cryoglobulin immune deposits affecting small vessels
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Rickettsial"
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"1) neisseria; pseudomonas
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Describe histology of giant cell (temporal arteritis
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"- segmental nodular thickening of arteries
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Describe hypersensitivity vasculitis
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"- e.g. leukocytoclastic vasculitis, microscopic polyarteritis
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Describe Buerger's dz (thromboangiitis obliterans)
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"- before 35yrso
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What are the typical Tx used for vasculitis?
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"1) glucocorticoids
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What is the relative frequency of primary cardiac tumors
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- extremely rare (<0.1% incidence)
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What are the clinical manifestations of cardiac tumors and their respective mechanisms
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"1) heart failure sx: osbtruction
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Describe cardiac myxomas
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"- most common primary tumor of heart in ADULTS
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Describe cardiac papillary fibroelastoma
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"- Second most common primary cardiac tumor
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Describe cardiac rhabdomyoma
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"- most common primary cardiac tumor in CHILDREN
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Describe cardiac fibroma
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"- second most common PEDIATRIC cardiac tummor (also in adults)
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What are the most frequently describe cardiac sarcomas?
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"1) angiosarcomas
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What is the prognosis for sarcomas of the cardiac tissue?
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"1) proliferate rapidly
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What are the most common tumors associated w/ cardiac involvement in mets?
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"1) malignant melanomas***
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Define: vasculitide
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1) the presence of leukocytes in the vessel wall with reactive damage to mural structures
What are the three different pathogenic models for the vasculitis disease process? |
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Define: vasculitide
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1) the presence of leukocytes in the vessel wall with reactive damage to mural structures
What are the three different pathogenic models for the vasculitis disease process? |
