Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
12 Cards in this Set
- Front
- Back
|
Apolipoprotein A function?
|
Activates LCAT (lecithin-cholesterol acyl transferase)
|
|
|
Apoliporotein B48 function?
|
Involved in receptor/lipoprotein interaction
Synthesized by intestine |
|
|
Apolipoprotein B100 function?
|
Involved in receptor/lipoprotein interaction
Synthesized by liver |
|
|
Apolipoprotein E function?
|
Involved in receptor/lipoprotein interaction
|
|
|
Apolipoprotein C function?
|
Activates LPL (lipoprotein lipase)
|
|
|
Chylomicron functions and synthesis?
|
Synthesized in intestine
Carrier of dietary TGs (primarily to adipose) Carrier of all dietary cholesterol to the liver only |
|
|
Chylomicron Remnants origin and fate?
|
Arises from chylomicron's interactions with LPL: as TGs are removed, (1) chylomicron shrinks, (2) PLs and cholesterol transferred to HDL, and (3) ApoC given back to HDL
Internalized by hepatocytes via receptor-mediated endocytosis, undergoing lysosomal degradation |
|
|
VLDL functions, synthesis, and apolipoproteins?
|
Synthesized by liver and contains no cholesterol esters
Carrier of TGs from liver and primarily to adipose Carrier of cholesterol from liver to other tissues ApoB100, ApoC/E (from HDL) |
|
|
LDL functions, synthesis, and apolipoproteins?
|
Synthesized by catabolism of VLDL and contains mostly cholesterol esters
Carries cholesterol between tissues Single copy of ApoB100 |
|
|
IDL functions, synthesis, apolipoproteins, and fate?
|
Synthesized during catabolism of VLDL to LDL
Carries TGs and cholesterol between VLDL and LDL ApoB100 and ApoE Either removed by liver or converted to LDL |
|
|
HDL function, synthesis, and apolipoproteins?
|
Synthesized in liver and intestine, containing mostly protein with some PL and cholesterol. Surface contains LCAT.
Transports cholesterol between tissues Scavenges unesterified cholesterol arising from (1) tissue turnover, (2) chylomicron degradation, and (3) VLDL degradation Once LCAT has esterified cholesterol, CEs are transferred to IDL/LDL ApoA |
|
|
CTEP function?
|
Transfers cholesterol esters and TGs between VLDL/LDL and HDL
|
