Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
21 Cards in this Set
- Front
- Back
|
Who are the Cortical Tumors?
|
Clear Cell RCC
Papillary RCC both from Renal Tubules |
|
|
Who are the Medullary Tumors?
|
Chromophobe RCC
Collecting Duct Carcinoma Renal Medullary Carcinoma all from intercalated cells of collecting ducts |
|
|
Key Points for Clear Cell RCC?
|
Cortical Renal Tubules
Most common Kidney cancer Lipid Rich Clear Cells Sporadic or Familial, but Loss of part of Ch 3 where VHL gene is Associate w/ Von Hippel Lindau |
|
|
Key points for Papillary RCC?
|
Cortical Renal Tubule origin
Second most common Specific Size Criteria (must be greater than .5 cm) Papillae w/ fibrovascular cores Sporadic and Familial w/ specific mutations and syndromes |
|
|
Key points for Sporadic Papillary RCC?
|
More common
Unilateral, maybe multifocal Trisomy 7, 17, 20 Loss of Y Chromosome |
|
|
Key points for Familial Papillary RCC?
|
Auto Dom
involves c-met oncogene on Ch 7 Trisomy of 7 in most cases Bilateral, multiple tumors |
|
|
Key Points for chromophobe RCC?
|
Medullary intercalated collecting duct epithelial origin
Third most common Clear pink cells w/ halos and solid cell walls (vegetable cells) Specific EM Sporadic and Familial Better Px than clear cell or papillary |
|
|
Kickers for sporadic chromophobe RCC?
|
27-86
M=F Mortality < 10% Loss of chromosomes |
|
|
Kickers for Familial Chromophobe RCC?
|
Birt Hogg Dube Syndrome
Ch 17-BHD gene |
|
|
Birt Hogg Dube sydrome =?
|
Multiple Chromophobe RCC's
Oncocytomas Papillary RCC Lung Cysts |
|
|
EM and Chromophobe RCC?
|
Numerous microvesicles around nucleus looks like a halo
Thick cell membranes |
|
|
Kickers for Collecting Duct Carcinoma?
|
Medullary, intercalated collecting duct epithelial origin
Pleomorphic Cells w/ gland formation High Nuclear Grade Aggressive Poor Px in comparison to previous 3 |
|
|
Kickers for Medullary Carcinoma?
|
Almost always in patiens w/ Sickle Cell
Young pts Males more than females Black/mediterranean Aggressive Very ugly pleomorphic cells Die w/in a year |
|
|
Kickers for Wilm's Tumor?
|
From embryonal nephrogenic rests
Primitive cells: spindles, blue cells, tubules Sporadic or Familial, but all about WT1 gene |
|
|
Familial Wilm's kickers?
|
Ch 11, WTI gene mutation
Multiple tumors 3 syndromes (WAGR, Denys-Drash, Beckwith-Weiderman |
|
|
Kickers for Oncocytomas?
|
Benign
Most common benign renal tumor From intercalated cells of collecting ducts Sporadic/Familial (BHD) Central Scar and Mahogany Brown Large Eosinophilc Cells Inc Mitochondria on EM |
|
|
Key Points for Ureteral and Bladder Tumors?
|
all derived from Urothelial cells (aka transitional)
Bening: papilloma Malignant: Urothelial Carcinoma (flat or papillary, low or high grade, invasive or non-invasive) Rarely Squamous Carcinoma and Adenocarcinoma |
|
|
Specific Risk Factors for Urothelial Carcinomas?
|
SMOKING
Occupation (aromatic amines in dye industry, late development) Drugs: long term analgesics, chemo Chronic UTI or stones Arsenic Radiation |
|
|
Low Grade UC genetics?
|
Ch 9 monosomy or deletions
Tumor suppressor gene affected |
|
|
High Grade UC genetics?
|
17, 11, 13, or 14
17: p53 13: retinoblastoma gene |
|
|
Risk factors for Squamous Cell Carcinoma of the bladder?
|
Chronic Irritation
Chronic indwelling catheters Shistosomiasis |
