Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
12 Cards in this Set
- Front
- Back
|
What are tumor suppressor genes?
|
PREVENT uncoord cell growth
-LOSS of FXN --> CANCER -BOTH alleles must be LOST |
|
|
Retinoblastoma, osteosarcoma
|
RB
(13q) |
|
|
Breast CA & Ovarian CA
|
BRCA1
(17q) |
|
|
Breast CA (ONLY)
|
BRCA2
(13q) |
|
|
Li-Fraumeni syndrome
-AND most human cancers! |
p53
(17q) |
|
|
Melanoma
"melaNoma is on Nine" |
p16
(9p) |
|
|
Colorectal CA
(assoc with FAP) |
APC
(5q) |
|
|
Wilm's Tumor
|
WT1
(11p) |
|
|
Neurofibromatosis Type 1
|
NF1
(17q) |
|
|
Neurofibromatosis Type 2
("Type 2 = 22") |
NF2
(22q) |
|
|
Pancreatic CA
|
DPC
(18q) (DPC = Deleted in Pancreatic Cancer) |
|
|
Colon CA
|
DCC
(18q) (DCC = Deleted in Colon Cancer) |
