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14 Cards in this Set
- Front
- Back
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APC |
Negative regulator of b-catein/WNT pathway Colorectal ca |
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BRCA 1/2 |
Dna repair Breast ovary and pancreatic ca |
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Cdkn 2a |
P16, blocks g1-s phase
Melanoma Pancreatic ca |
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Dcc |
Colon cancer |
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Smad 4 (dpc) |
Pancreatic cancer |
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Men 1 |
Menin Men 1 |
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NF 1 |
Neurofibromin (ras gtpase activating protein) Neutofibromatosis type 1 |
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NF2 |
Merlin (schwanomin protein ) Neurofibromatosis 2 |
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PTEN |
Negatively regulates p13/akt pathway Breast Prostate Endometrial ca |
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Rb |
Inhibits e2f, blocks g1-s phase Retinoblastoma Osteosarcoma |
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Tp53 |
Activates p21 and blocks g1 - s phase Li fraumeni syndrome (sbla ) (sarcoma, breast leukemia and adrenal ) |
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Tsc 1 Tsc 2 |
Tsc 1- hamartin Tsc 2 - tuberin
Both for tuberous sclerosis |
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vhl |
Inhibits hypoxia inducible factor 1a Von hipple lindau dz |
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Wt 1 |
Transcription factor regulates urogenital development Wilms tumor (nephroblastoma) |
