• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/11

Click to flip

11 Cards in this Set

  • Front
  • Back
Rb
normally blocks G1-S transition

loss --> retinoblastoma, osteosarcoma
p53
normally blocks G1-S transition

loss --> most cancers, Li-Fraumeni syndrome (germline mutation --> cancer suceptibility)
BRCA1
normally repairs DNA

loss --> breast and ovarian cancer
BRCA2
normally repairs DNA

loss --> breast cancer
p16
loss --> melanoma
APC
loss --> familial adenometous polyposis and colorectal cancer
WT1
loss --> Wilms' tumor (nephroblastoma)
NF1
loss --> neurofibromatosis 1
NF2
loss --> neurofibromatosis 2
DPC
loss --> pancreatic cancer
DCC
loss --> colon cancer