Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
12 Cards in this Set
- Front
- Back
|
Which innate cells are the most important in the response against tumors?
|
NK cells
|
|
|
Can NK cells distinguish between the presence of an activating receptor with a concurrent lack of an inhibitory receptor?
|
yes
|
|
|
What does a NK cell do when it encounters a cell with an activating rceptor, without the presence of a concomitant inhibitory receptor?
|
kills the cell
|
|
|
Which T cell sub set is the most important in mounting a toxic response to tumor cells?
|
CTL's !!! (CD8)
|
|
|
What CD4 cells are most active against tumor cells?
|
Th1 response which will make cytokines, to ramp up macros or NKs
|
|
|
What major cytokine do NKs make in this process?
|
IFN gamma
|
|
|
What humoral componenet is instumental in attenuating the metastais of the cells?
|
IgG, important to stop the spread
|
|
|
What kind of vaccine is based upon dendritic cells pulsed with tumor Ags or cells transfected with genes encoding tumor Ags?
|
professional APC-based vaccines
|
|
|
What is a humanized mouse monoclonal Ab that is approved for the use in breats cancer?
|
Her-2/Neu
|
|
|
What specific Ab is a B cell marker, made from a humanized mouse monoclone, and has been used in clinical trial to treat B cell lymphoma?
|
CD20
|
|
|
What is the name of an antibody linked with a highly toxic biological substance that can be transported to the tumor?
|
immunoconjugate
|
|
|
What can kill tumor cells by many mechanisms independent of recruitment of effector cells or complement?
|
modified mAbs
|
