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48 Cards in this Set
- Front
- Back
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abl
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oncogene
CML, ALL |
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c-myc
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oncogene
Burkitt's lymphoma |
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bcl-2
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oncogene (inhibits apoptosis)
Follicular and undifferentiated lymphomas |
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erb-B2
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oncogene
breast ca ovarian ca gastric ca |
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ras
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oncogene
colon ca bladder ca lung ca pancreas ca kidney ca |
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L-myc
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oncogene
lung tumor |
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N-myc
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oncogene
neuroblastoma small cell ca of lung |
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ret
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oncogene
MEN II and III |
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c-kit
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oncogene
gastrointestinal stromal tumor (GIST) |
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erb-B1
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oncogene
squamous cell ca of lung |
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sis
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oncogene
astrocytoma osteosarcoma |
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TNFa
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oncogene
astrocytoma HCC |
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Rb
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13q
tumor suppressor retinoblastoma osteosarcoma |
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BRCA1
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17q
tumor suppressor-DNA repair breast ca ovarian ca |
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BRCA2
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13q
tumor suppressor breast ca |
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p53
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17p
tumor suppressor most human cancers Li-Fraumeni syndrome |
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p16
|
9p
tumor suppressor melanoma |
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APC
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5q
tumor suppressor colorectal ca assoc with FAP pancreas ca |
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WT1
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11p
tumor suppressor Wilms' tumor |
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NF1
|
17q
tumor suppressor NF1 sarcomas |
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NF2
|
22q
tumor suppressor NF2 |
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DPC
|
18q
tumor suppressor pancreatic ca |
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DCC
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18q
tumor suppressor colon ca |
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prostate-specific antigen (PSA)
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screen for prostate ca
also elevated in BPH, prostatitis |
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prostatic acid phosphatase
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prostate ca
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carcinoembryonic antigen (CEA)
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colorectal and pancreatic ca
gastric and breast ca nonspecific |
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a-fetoprotein
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hepatocellular ca
nonseminomatous germ cell tumors of testis |
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b-hCG
|
hydatidiform moles
choriocarcinoma gestational trophoblastic tumors |
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CA-125
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ovarian ca
maliganant epithelial tumors |
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S-100
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melanoma
neural tumors astrocytomas |
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alkaline phsophatase
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mets to bone
obstructive biliary dz Paget's dz of bone |
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bombesin
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neuroblastoma
lung and gastric ca |
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tartrate-resistant acid phosphatase (TRAP)
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hairy cell leukemia (B cell neoplasm)
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CA-19-9
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pancreatic adenocarcinoma
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aflatoxins
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produced by aspergillus
hepatocellular ca |
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vinyl chloride
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liver - angiosarcoma
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CCl4
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liver-centrilobular necrosis, fatty change
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nitrosamines
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in smoked food
esophagus, stomach |
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cigarette smoke
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larynx - squamous cell ca
lung - squamous and small cell ca kidney - renal cell ca bladder - transitional cell ca |
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arsenic
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skin - squamous cell ca
liver - angiosarcoma |
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naphthalene (aniline) dyes
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bladder - transitional cell ca
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alkylating agents
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blood - leukemia
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t(9;22)
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philadelphia chromosome
CML (bcr-abl hybrid) |
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t(8;14)
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burkitt's lymphoma (c-myc activation)
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t(14;18)
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follicular lymphomas (bcl-2 activation)
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t(15;17)
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M3 type of AML
responsive to all-trans retinoic acid auer rods |
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t(11;22)
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ewing's sarcoma
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t(11;14)
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mantle cell lymphoma
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