Tropical Medicine Week 1

Front 1

Rabies definition

Back 1

Lyssavirus. Zoonosis of mammalian carnivores. 11 Genetic virus in this Genus. Genotype 1 = Rabies virus. Genotype 7 = Australian Bat Lyssa

Front 2

Pathogenis

Back 2

Neurtropic virus (likes the nerves)
No detectable viraemia till late.
Once virus in nerves sequestered away from the immune response. Travels slowly to the CNS along nerves. Causes encephalomyelitis. Always fatal

Front 3

Pathognomonic for Rabies

Back 3

Hydrophobia

Front 4

Diagnosis

Back 4

Hx - Animal Bite (did the dog die- pos for Rabies)
Hydrophobia
Blood Tests (Too Late)
PCR (Saliva, nuchal biopsy, cornea, brain biopsy)
Negri inclusion bodies (pathognomonic)

Front 5

Tx and prevention

Back 5

Prevention strategies public health
Pre exposure prophylaxis- Vaccine
Post exposure prophlaxis (wound management, vaccine and immunoglobulin)
Canine Rabies control

Front 6

Prevalence

Back 6

55, 000 deaths a year in Africa and Asia under recognised and under reported

Front 7

Symptoms

Back 7

<1 week to >1 year incubation but average 1-3 months.
Initial- Fever, unusual pain at wound site
2 types-
Furious- hyperactive, excited, hydrophobia and airphobia.
Death by cardio-resp arrest.
Paralytic, 30%. Paralysis at start of bite, slow progression, coma and then death,