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15 Cards in this Set
- Front
- Back
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Give the visceral Leishmainiasis effects on the following organs:
1. Lymph glands 2. Spleen 3. Bone marrow 4. Liver |
1. enlarged, congested, marked proliferation of histiocytes and lymphocytes
2. enlarged, pulp histiocytes and sinusoidal lining cells packed with parasites 3. hyperplastic, many histiocytes contain the parasite 4. kupffer cells packed with parasites |
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What are the signs and symptoms of visceral leishmaniasis
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fever, weight loss, anorexia, HSM, pallor, hair: dry, skin: dry and hyperpigmented, pedial edema,
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What does L. donovani donovani cause
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exuberant tumor in the mouth with nasal involement and scanty amastigotes
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What is PKDL
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post kala-azar dermal leishmaniasis
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what are the 3 forms of PKDL and which responds well to therapy
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macular (has good response"Mac-daddy")
mixed nodular |
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What is visceral leishmaniasis peripheral blood analysis?
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microcytic anaemia
leucopenia thrombocytopenia and defective coagulation |
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what is seen on protein electrophoresis of leishmaniasis?
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hypergammaglobulinaemia and low albumin
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where can DONOVAN BODIES be demonstrated in leishmaniasis? (5 places)
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1. peripheral blood
2. Bone marrow 3. spleen 4. lymph nodes 5. liver |
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What is the Katex test?
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latex agglutination test to detect leishmanin antigen in URINE.
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What is Leishmaniasis treatment?
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1. organic pentavalent antimonials (20-28 days):
a. Na+ stibogluconate or b. Meglumin antimoniate 2. pentavalent antimonials +allopurinol (20-28 days) or aminosidine 3. aminosidine (up to 64 days) 4. Amphotericin B 5. Miltefosine 6. Pentamidine |
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What are the adverse effects of the pentavalent antimonials?
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1. GIT
2. ECG changes (dose related) 3. circulatory collapse |
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Give two methods of control of visceral leishmaniasis:
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1. reduce the animal reserviors
2. control vectors |
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What are 4 methods to control the vectors:
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1. impregnate nets
2. repellents (hexmethylene benzamide/insecticide 3. remove rubbish and organic matter from around dwellings 4. remove sandfly bredding grounds: bricks, firewood etc. |
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What is Leishmaniasis vector?
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Sandfly
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Where is V. leishmaniasis endemic?
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S. america, Africa (north/west), India, Southern Europe
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