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15 Cards in this Set
- Front
- Back
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Lassa virus:
1. give the class of virus: 2. how is it transmitted? 3. what is the reservoir? |
1. Arenavirus (segmented RNA virus, 2 linear strands in glycoprotein)
2. contact, urine 3. field rat |
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Marburg Virus:
1. give the class of virus: 2. how is it transmitted? 3. what is the reservoir? |
1. Filovirus
2. close contact 3. fruit bats *like ebola |
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Ebola virus:
1. give the class of virus: 2. how is it transmitted? 3. what is the reservoir? |
1. FiloVirus
2. close contact 3. fruit bats *like marburg |
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Dengue HF:
1. give the class of virus: 2. how is it transmitted? 3. what is the reservoir? |
1. Flavivirus
2. Aedes 3. no reservoir *like yellow fever |
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SAHF:
1. give the class of virus: 2. how is it transmitted? 3. what is the reservoir? |
1. Arenavirus (segmented RNA virus, 2 linear strands in glycoprotein)
2. contact 3. rodent *like lassa |
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Yellow Fever
1. give the class of virus: 2. how is it transmitted? 3. what is the reservoir? |
1. Flavivirus
2. Aedes 3. monkeys and people *like dengue |
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Where is lassa virus?
-cases/deaths per year: |
W. africa
-3 million case/67,000 deaths |
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What is sequalea of Lassa fever?
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1. deaf, neurological damage
2. pericarditis 3. high mortality in third trimester pregnancy and abortion |
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What is the disease presentation (in a nutshell)?
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Incubation about 1 week, then everywhere in the body is very sick and MOF, with easy bleeding (GIT, mucous membrane)/bruising
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Is there immunity/vaccine to lassa?
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1. natural immunity
2. antibody to glycoprotein and live attenuated vaccine that work in animals, not yet tried in people. |
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Diagnosis for haemorrhagic fever:
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1. serolgy (ELISA, IF)
2. EM 3. culture virus 4. PCR *use category 4 biosafety |
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treatment for haemorrhagic fever:
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1. Intensive care (fluids, O2, electrolytes, transfuse, iontropes)
2. ribavirin in lassa helps (but not in ebola/marburg) 3. reservoir control etc. |
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How does ebola/marburg present?
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1. really sick
2. haematological signs: bleeding, rash, conjuctival injection 3. DIC, shock, metabolic change |
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Outcome of ebola/marburg?
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1. 25-80% mortality
2. survivors have athralgia and psychosocial change |
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what lab results from ebola/marburg?
-any treatment for ebola/marburg |
1. leucopenia/lymphopenia/ thrombocytopaenia
2. neutrophilia/raised LFTs -treatment: not much, supportive care, transfusion from survivors |
