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30 Cards in this Set
- Front
- Back
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What is the MOA of typical antipsychotics? |
1. Block D2 receptors
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What is the MOA of atypical antipsychotics? |
1. Block 5-HT2 receptors 2. Block D2 receptors with low affinity |
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What are the adverse effects of atypical antipsychotics? |
1. Metabolic syndrome 2. DM 3. Obesity |
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What are the main atypical antipsychotics classifications? |
1. Phenothiazines 2. Butyrophenones |
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What are the phenothiazines? |
1. Chlorpromazine 2. Thioridazine 3. Trifluoperazine 4. Fluphenazine 5. Prochloperazine |
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What is the butyrophenone? |
1. Haloperidol |
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What are the side effects of typical antipsychotics? |
EPS--- Early: Parkinson-like symptoms, akathisia, acute dystonia
Late: tardive dyskinesia |
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How do you tx 2o akathisia due to typical antipsychotics? |
1. BB 2. Benzodiazepines 3. Anticholinergic drugs |
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How do you tx Parkinsonism due to typical antipsychotics? |
1. Benztropine 2. Diphenhydramine 3. Amantadine |
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How do you tx tardive dyskinesia due to typical antipsychotics? |
1. Benzodiazepines
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What are the cardiac side effects of typical antipsychotics? |
1. Prolongation of QT 2. Torsades |
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What is the MCC of neuroleptic malignant syndrome? |
1. Typical antipsychotics |
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What are the ssx of neuroleptic malignant syndrome? |
1. Fever 2. Muscular rigidity 3. Confusion/stupor 4. Dysrhythmias and BP fluctuation |
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How do you tx neuroleptic malignant syndrome? |
1. Supportive 2. Bromocriptine 3. Dantrolene |
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What is the clinical use of chlorpromazine? |
1. Positive symptoms of schizophrenia 2. Bipolar disorder 3. Suppression of emesis |
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What is the clinical indication of loxapine? |
1. Schizophrenia |
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What is the most effective antipsychotic drug? |
1. Clozapine |
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What is the clinical use of clozapine? |
1. Tx-resistant schizophrenia |
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What are the adverse effects of clozapine? |
1. Agranulocytosis 2. Sedation 3. Tachycardia |
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What is the MOA of aripiprazole? |
1. 5-HT2 antagonist 2. Partial D2 agonist |
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What is the MOA of lurasidone? |
1. 5-HT2 antagonist 2. Weak D2 antagonist |
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What is the clinical use of aripiprazole? |
1. Schizophrenia 2. Bipolar 3. Major depressive disorder |
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What is the black box warning for aripiprazole? |
1. Increased mortality in elderly patients with dementia-related psychosis |
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What is the MOA of asenapine? |
1. Combination of antagonist at D2 and 5-H2A receptors |
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What is the indication for asenapine? |
1. Schizophrenia 2. Bipolar disorder |
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What is the black box warning for asenapine? |
1. Increased mortality in elderly patients with dementia-related psychosis |
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What is the indication for lurasidone? |
1. Schiophrenia 2. Bipolar |
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What is the clinical use for lithium and valproate? |
1. Bipolar disorder |
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What is the general tx for bipolar disorder? |
1. Mood stabilizers--- lithium, valproate, carbamzepine, lamotrigine 2. Atypical antipsychotics for manic phase 3. Antidipressants |
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What drug is used to tx nightmares and sleep disturbance in PTSD? |
1. Prazosin (a1 antagonist) |
