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18 Cards in this Set
- Front
- Back
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Which symptoms of parkinsons respond best to L-DOPA?
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bradykinesia, rigidity
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Which symptom is "resistant" to L-DOPA therapy in parkinsons?
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tremor
also little improvement in dementia |
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Why is L-DOPA used instead of dopamine?
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dopamine can't cross the BBB while L-DOPA can
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What is a trick to increasing L-DOPA absorption from the GI tract?
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Low protein meal or empty stomach
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Why does L-DOPA cause arrhythmias?
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increases peripheral dopamine also and dopamine stimulates Beta receptors
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What can be given with L-DOPA to decrease peripheral conversion of L-DOPA to dopamine
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carbidopa
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Central adverse effects of L-DOPA
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nausea and vomiting (develop tolerance)
dyskinesias, chorea mental disturbance or psychosis (can use clozapine to treat because little if any D2 block) |
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Mechanism of selegiline
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selective MAOb inhibitor thereby proloning activity of dopamine in brain
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Trihexyphenidyl and Benzotropine Mesylate are?
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centrally acting anticholinergics used in early or mild Parkinson's disease
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Contraindications to Trihexyphenidyl and Benztropine mesylate
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BPH
paralytic ileus narrow angle glaucoma remember these are ANTICHOLINERGICS |
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Major contraindication for selegiline
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meperidine = malignant hyperthermia
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Amantadine is useful in Parkinson's disease because
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NMDA receptor antagonist
short lived amphetamine like effect |
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Amantadine is eliminated?
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renally
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When can direct dopamine agonists be used?
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while L-DOPA is still effective (need the receptors there)
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COMT inhibitors
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-capone
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Treatment for essential tremor
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propranolol
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Haloperidol mechanism of action
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dopamine antagonist - decrease dopamine and increase acetylcholine
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Mechanism of action for memantine
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NMDA receptor antagonist (used in alzheihmers)
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