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15 Cards in this Set

  • Front
  • Back
Classic Angina
-Occlusion of coronary arteries resulting from the formation of athersclerotic plaques
-Most common form of angina
-Symptoms occur during exertion/stress
-High Cholesterol= #1 Risk Factor
Variant Angina
-Spontaneous vasoconstriction of coronary arteries
-Likely genetic in origin
-Symptoms occur at rest
Stable Angina
Partial occlusion of coronary artery
Symptoms only during exertion
Unstable Angina
Partial occlusion of coronary artery w/ sudden, intermittent vasoconstriction.
-Symptoms increase in frequency and begin to occur at rest
Normal Lipid Metabolism
1-Chylomicrons transport cholesterol and triglycerides
2-Lipoprotein Lipase cleaves triglycerides from chylomicrons leaving cholesterol in liver
3-Liver packs cholesterol and triglycerides together as VLDL
4-Lipoprotein Lipase breaks down VLDL releasing triglycerides. Produces IDL which is taken up by liver or converted to LDL.
5-LDL delivers cholesterol to cells by binding to LDL receptor on cells
6-HDL is synthesized in the liver. Stimulates lipoprotein lipase and acquires cholesterol from other sites and returns it to the liver to be excreted
Increased VLDL
-Some risk for coronary heart disease
Increased LDL
-HIgh risk for coronary heart disease
Tx of Hyperlipidemia
1. Decrease the amount of lipid entering the blood (Diet)
2. Improve the clearance of lipid from the blood
-VLDL-->Lipoprotein Lipase
-LDL-->LDL Receptors
Drugs used for tx of hypertriglyceridemia
Fibric Acid Derivatives
Drugs used for Tx of hypercholesterolemia
Bile-acid binding resins
Combo Therapy
Used to treat hypertriglyceridemia
-Inhibits VLDL synthesis in liver
-Stimulates lipoprotein lipase acitivity (breakdown of VLDL)
-Increases HLD levels
-Net decrease in LDL
Fibric Acid Derivatives
-Used to treat hypertriglyceridemia
-Inhibits VLDL synthesis in liver
-Stimulates breakdown of VLDL by lipoprotein lipase
-No change in LDL levels
Bile-Acid Binding Resins
-Used to treat hypercholesterolemia
-Reduces LDL levels
-Prevents bile acid reabsorption
-Greater conversion of cholesterol to bile acids and lower liver cholesterol levels
-Lower cholesterol levels stimulate up-regulation of LDL receptors which increases LDL uptake from blood
Atorvastatin (Lipitor)
-Used to treat hypercholesterolemia
-HMG-CoA Reductase Inhibitor
-Inhibits cholesterol synthesis in liver-->upregulation of LDL receptors, results in increased removal of LDL from blood.
--Side Effects--
Usually safe with mild GI effects
Low incidence of liver toxicitiy
Low incidence of rhabdomyolysis
-Used to treat hypercholesterolemia
-Inhibits intestinal cholesterol absorption
1.Reduces dietary cholesterol absorption
2.Reduces re-absorption of cholesterol secreted in bile
**May induce rhabdomolysis by itself or increase risk for statin-induced rhabdomyolysis