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34 Cards in this Set

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MOST COMMON CAUSE OF DEMENTIA IS _ FOLLOWED BY _ AND _
ALZHEIMERS DISEASE

VASCULAR DEMENTIA

LEWY BODY DEMENTIA
2 FORMS OF ALZHEIMERS DISEASE
FAMILIAL

LATE ONSET
_ AND _ ARE PATHOLOGICAL HALLMARKS OF ALZHEIMERS DEMENTIA
NEURITIC PLAUES

NEUROFIBRILLARY TANGLES
NAME 2 CLASSES OF DRUGS THAT ARE USED IN TREATMENT OF ALZHEIMERS DEMENTIA
ANTI-CHOLINESTERASE INHIBITORS

NMDA ANTAGONISTS
WHICH PROTEIN IS MUTATED IN AD AND ON WHAT CHROMOSOME
APP (AMYLOID PRECURSOR PROTEIN) ON CHROMOSOME 21

PRESENILIN 1 AND 2 (PROCESSING APP)
AD RISK FACTORS
AGE

DOWNS SYNDROME

APOLIPOPROTEIN ALLELES

MUTATION OF APP ON CHROMOSOME 21 AND PRESENILIN PROTEINS
WHAT IS THE EARLIER INDICATOR OF DEMENTIAL - BETA AMYLOID PLAQUE OR NEUROFIBRILLARY TANGLES
BETA AMYLOID PLAQUE
DESCRIBE FORMATION OF BETA AMYLOID PLAQUE
NORMALLY BETA AND GAMMA SECRETASE CLEAVE APP AND MAKE BETA AMYLOID - 40 AA SEQUENCE THAT IS SOLUBLE

IN ALZHEIMERS ITS A 42-43 AA SEQUENCE THAT IS INSOLUBLE AND IT ACCUMULATES
WHICH PRO INFLAMMATORY CYTOKINE IS HALLMARK OF AD
TNF ALPHA
DESCRIBE SIGNIFICANCE OF TAU PROTEIN IN AD
TAU PROTEIN IS ESSENTIAL FOR CONSTRUCTION OF MICROTUBULES WHICH ARE RESPONSIBLE FOR INTERNEURON COMMUNICATION, WITHOUT IT THEY WILL FORM NEUROFIBRILLARY TANGLES - HAPPENS IN AD
WHICH NT IS MISSING IN AD
ACH
_ PROTEINS ARE KNOW TO CAUSE MOST SEVERE FORM OF FAMILIAL AD
PRESINILIN 1 AND 2
NAME ALL DRUGS USED IN MANAGEMENT OF AD
ANTI CHOLINESTERASE INHIBITORS

NMDA ANTAGONISTS

VITAMIN E (ANTI OXIDANTS)

ESTROGEN

ANTI INFLAMMATORY DRUGS
WHAT ARE THE MAJOR CHOLINERGIC CHANGES IN AD
DEPLETION OF ACH

LESS CHAT ACTIVITY

DEPLETION OF CHOLINERGIC NEURONS (MUSCARINIC AND NICOTINIC)
FIRST AD DRUG TACRINE IS NOT USED ANY MORE - WHY?
LIVER TOXICITY + SHORT T1/2
WHICH MEDICATIONS ARE USED TO ENHANCE COGNITIVE FUNCTION
CHOLINESTERASE INHIBITORS:

TACRINE

DONEPEZIL

RIVASTIGMINE

GALANTAMINE
NAME NMDA ANTAGONIST THAT IS ALSO USED FOR TREATMENT OF SUBARACHNOID HEMORRHAGE AND STROKES
MEMANTINE
_ ARE INDICATED FOR TREATMENT OF MILD TO MODERATE AD
CHOLINESTERASE INHIBITORS
NAME CHOLINESTERASE INHIBITOR WITH SPECIFICITY FOR INHIBITING ACETYLCHOLINESTERASE AS COMPARED TO BUTYLCHOLINESTERASE
DONEPEZIL
DONEPEZIL CONCENTRATION CAN BE INCREASED IF CO-ADMINISTERED WITH _
CIMETIDINE OR KETOKONAZOLE - P450 INHIBITORS
WHAT IS THE FOOD RESTRICTION FOR PEOPLE TAKING DONEPEZIL
GRAPEFRUIT JUICE (CYTOCHROME P450 INHIBITOR)
DRUGS WITH ANTI-CHOLINERGIC PROPERTIES SUCH AS _ COUNTERACT THE EFFECTS OF DONEPEZIL AND SHOULD BE AVOIDED DURING THERAPY WITH DONEPEZIL
ATROPINE

BENZTROPINE

TRIHEXYPHENIDYL
NAME DRUG THAT HAS CENTRAL ACTIVITY IN BOTH ACETYLCHOLINESTERASE AND BUTYLCHOLINESTERASE
RIVASTIGMINE
TOLERABILITY AND ABSORPTION ARE IMPROVED WHEN RIVASTIGMINE IS GIVEN _
WITH FOOD
IS THERE A POTENTIAL FOR DRUG DRUG INTERACTIONS WITH RIVASTIGMINE
NOT MUCH - LOW PROTEIN BINDING AND IS NOT METABOLIZED BY P450
_ SIDE EFFECTS ARE MOST COMMON WITH RIVASTIGMINE
CHOLINERGIC
WHICH AD DRUG CAUSES NAUSEA, VOMITTING, DIARRHEA, MUSCLE CRAMPS AND RHINITIS
DONEPEZIL
WHICH DRUG CAUSES NAUSEA, VOMITTING, DIARRHEA AND WEIGHT LOSS
RIVASTIGMINE
WHICH DRUG IS APPROVED FOR TREATMENT OF MODERATE TO SEVERE AD
MEMANTINE
MECHANISM OF ACTION FOR MEMANTINE?
NMDA ANTAGONIST
WHICH AD DRUG CAUSES MUSCLE CRAMPS AND RHINITIS
DONEZEPIL
WHICH AD DRUG CAUSES WEIGHT LOSS
RIVASTIGMINE
WHICH AD DRUG CAUSES VERTIGO
GALANTAMINE
WHICH AD DRUG CAUSES VERTIGO AND CONFUSION
MEMANTINE