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23 Cards in this Set
- Front
- Back
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Stage I NSCLC:
a.) surgery? b.) radiation? c.) chemo? |
a.) YES!! first line
b.) NO! c.) NO! |
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Stage II NSCLC
a.) surgery? b.) radiation? c.) chemo? |
a.) Yes!
b.) maybe as adjuvant or neoadjuvant c.) maybe, if unresectable/ adjuvant |
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Stage III NSCLC
a.) surgery? b.) radiation? c.) chemo? |
a.) YES!
b.) maybe, as adjuvant or neoadjuvant c.) maybe, if unresectable/adjuvant |
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ALK mutation 1st line
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crizotinib
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Stage IV NSCLC
a.) surgery? b.) radiation? c.) chemo? |
a.) for palliation only
b.) for palliation only c.) if ok performance status, use platinum based therapy. if ECOG 3-4, don't use chemo bc won't benefit |
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NSCLC adjuvant chemotherapy
a.) what is the standard of care? (class) b.) actual drugs (2 sets) |
a.) platinum (bc it improves 5 year overall survival)
b.) cisplatin + vinorelbine OR carboplatin + paclitaxel |
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NSCLC neoadjuvant chemotherapy
a.) standard of care (class) b.) actual drugs |
a.) platinum chemo + radiation
b.) cisplatin + etoposide or vinblastine |
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NSCLC metastatic chemotherapy
a.) good PS b.) bad PS |
a.) doublet: cisplatin or carboplatin + taxel/ vinca/ topo/ irino/ pemetrexed
b.) monotherapy. don't do chemo |
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NSCLC metastatic chemotherapy: mesothelioma
a.) drugs |
a.) cisplatin + pemetrexed
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Pemetrexed
a.) indication (2) b.) backbone c.) pre-medication (3) |
a.) mesothelioma, non-squamous cell carcinoma (adenocarcinoma)
b.) cisplatin c.) folic acid, b12, dexamethasone |
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NSCLC: ALK & EFGR negative, chemotherapy options
a.) squamous cell carcinoma b.) non squamous cell carcinoma |
a.) cisplatin + gemcitabine
b.) cisplatin + pemetrexed |
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Bevacizumab
a.) MOA b.) indication (2) c.) use with (2) d.) ADR |
a.) binds to VEGF
b.) colorectal cancer, 1st line nonsquamous NSCLC c.) carboplatin & paclitaxel d.) blood dyscrasia (thrombocytopenia, neutropenia, hemorrhage, HTN) |
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What ab is first line for non squamous NSCLC (and ECOG 0-1)?
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bevacizumab + carboplatin + paclitaxel
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Cetuximab
a.) MOA b.) indication c.) use with d.) ADR |
a.) binds to EGFR
b.) colorectal cancer, not approved for NSCLC (but recommended to use for EGFR + and good performance ECOG 0-1) c.) cisplatin + vinorelbine d.) acneiform rash |
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EGFR & ALK both negative
a.) how to treat |
a.) based on performance status
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Erlotinib
a.) indication b.) DI (3) c.) use with d.) MOA |
a.) EGFR (+) & NSCLC non-squamous (regardless of performance status)
b.) empty stomach, PPI/H2RA, CYP3A4 substrate c.) no combo chemo necessary d.) EGFR TKI |
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1st line for EGFR(+)
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erlotinib or afatinib
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Afatinib
a.) indication b.) MOA c.) use with |
a.) 1st or 2nd line EGFR+ mutation NSCLC
b.) TKI for EGFR & HER2/HER4 c.) no combo chemo necessary |
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Crizotinib
a.) indication b.) DI (2) c.) take with |
a.) ALK+ NSCLC
b.) cyp 3A4 substrate, with or without food c.) no combo chemo needed |
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SCLC stage I
a.) surgery? b.) radiation? c.) chemo? |
a.) yes. THIS IS THE ONLY STAGE IT IS APPROPRIATE IN SCLC. all other stages, surgery has no role!
b.) yes c.) yes *chemo and radiation are given together |
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Limited SCLC
a.) chemo drugs (2 sets) b.) take with |
a.) cisplatin + etoposide or carboplatin + etoposide
b.) radiation |
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Extensive SCLC
a.) chemo drugs (3 sets) b.) take with |
a.) cisplatin + etoposide // carboplatin + etoposide // cisplatin + irinotecan
b.) radiation for symptom relief only, is not required, unlike limited SCLC |
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Extensive SCLC: relapse
a.) type of therapy b.) can you use same regimen as before? |
a.) monotherapy
b.) yes if relapse > 6 months from when last used |
