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Yellow Book

CDC resource

traveler's diarrhea

Asia, Middle East, Africa, Mexico, Central and South America




3+ unformed stools/day + cramping, N/V


E.coli




untreated: 3-7 days

traveler's diarrhea prophylaxis

bismuth subsalicylate

traveler's diarrhea treatment

hydration


increased salt intake


loperamide 4 mg after 1st loose stool, then 2 mg after each subsequent day


-max 8 mg/day for up to 2 days


bismuth subsalicylate


abx (quinolones, marolides) if moderate - severe

typhoid fever

salmonella


Asia, Africa, Caribbean, Central/South America


food/water contaminated w/ feces, acute infection carrier, or chronic asymptomatic carrier




incubation period: 6-30 days




fatigue, fever increasing over 3-4 days, HA, malaise, anorexia, enlargement of liver/spleen, transient rash



typoid fever vaccines

vivotif (live, oral)


typhim Vi (inactivated, IM


-2 weeks before exposure




50-80% effective- wash hands frequently and be careful with food/water

cholera

vibrio cholerae


Africa, Southeast Asia, Haiti




diarrhea ("rice water stools), vomiting, dehydration





cholera vaccine

vaxchora


live


single, oral liquid dose


>10 days before travel

hepatitis A

traveling to developing countries


fever, malaise, jaundice, nausea, abdominal discomfort up to 7 weeks

hepatitis B

contaminated blood or bodily fluids


incubation period 90 days


malaise, jaundice, nausea, abdominal discomfort




3 dose vaccine - 6 months to complete


-may complete as many doses as possible before departure and finish upon return


-high risk: accelerated series

meningococcal meningitis

n. meningitidis


fever, severe headache, nausea, stiff neck


Africa December-June, Saudi Arabia during Hajj and Umrah pilgrimage




quadrivalent vaccine

Polio

Afghanistan, Burma (Myanmar), Guinea, Laos, Nigeria, Madagascar, Pakistan, Ukraine




if spending > 4 weeks there, 1 time booster at least 4 weeks prior to travel

insect bites

20-50% DEET


permethrin for clothing, gear, bed nets

dengue

mosquitos


no vaccine


treatment: supportive care

malaria

Asia, Latin America, North Africa, Eastern Europe, South Pacific


P. vivax = 50% of cases in India


P. falciparum = most deadly

Malaria Prophylaxis

Atovaqone/Proguanil (Malarone)


250/100 mg PO daily w/ food or milk


start 1-2 days pre-travel, stop 7 days post


do not use in pregnancy or CrCl <30




Primaquine 30 mg PO daily w/ food (nausea)


start 1 day pre-travel stop 7 days post


do not use if G6PD deficiency or pregnancy




Mefloquine (Larium) 250 mg PO weekly w/ food/water


start 2-3 weeks pre-travel stop 4 weeks post


do not use w/ neuropsychiatric disorders


OK in pregnancy




Chloroquine (Aralen) 500 mg PO weekly w/food


start 1-2 weeks pre-travel stop 4 weeks post


CrCl < 10: use 50% dose


OK in pregnancy




Doxycycline (Vibramycin) 100 mg daily w/ food


start 1-2 weeks pre-travel, stop 4 weeks post


OK in pregnancy

Japanese Encephalitis

mosquitos




vaccine: Ixiaro for travelers > 2 months who plan to spend at least 1 month in endemic areas during season

Yellow fever

tropical areas in South America and Africa


mosquitos


asymptomatic or flu-like symptoms


do not use aspirin or NSAIDs




vaccine: single dose = lifelong protection


-high risk of adverse effects: fever, headache, neurologic disease


-CI in patients w/ hypersensitivity to eggs

Zika

mosquito, sexual, blod transfusion

fever, maculopapular rash, arthralgia, conjuntivitis


No vaccine yet

Motion sickness

acetazolamide (diamox) 125 mg BID, started the day before or day of ascent


prophylaxis for mountain sickness


CI w/ sulfa allergy