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19 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Syngeneic
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identical genetic match ( self and clones)
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Allogeneic
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same species not twins
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Xenogeneic
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major gen differences
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Autograft
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self tissue
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isograft
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between syngeneic indviduals (twins or clones)
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allograft
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same species not twins
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xenograft
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between xenogeneic ind.
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MHC
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closely linked family of polymorphic genes which encode for cell surface histocompatibility antigens responsible for transplant rejection
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Allograft rejection timetable
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2-4 Days- Graft pale, then appears pink
4-7- gragt becomes cyanotic and necrotic infiltration of mononuclear cells and thrombosis 10-12- macroscopic rejection |
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Rejection determined by (5)
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Degree of gen difference
quantity type of tissue immune status of host previous exposure |
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Three phases of allograft rejection
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Recognition
Proliferation Destruction |
Recog- APC cells go to lymph nodes primarily CD4+ cells
Prolif- CD4 cells and pacmans mediate the induction of proliferation of T and B cells Destro- CD8 cells primary force cytolysis from perforins granzyme apoptosis B cells go to plasma cells C5a lysis and ADCC via K NK cells |
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Tissue matching
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HLA molecule study
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MHC Classes
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Class I- A,B,CTLs
class II- D DP DQ DR CD4 |
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Tissue typing
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PCR technique to see how different
not correlative between number of dif and severity of rejection |
might be MINOR HISTO antigens in perfect match
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Mixed leukocyte culture test
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mimics proliferation by measuring hosts CD4 cells against donor cells (HLA D targeted)
class I secondary explain?? |
responder cells
stimulator cells stimulator cells recieve one way irradition to stop there reactivty against host mix for several days see rate of proliferation |
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Immune suppresants
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radiation
cytotoxic chemotherapy |
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Graft V Host
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CD4 and inflamattion get out of hand, host loses intestinal mucosa, mononuclear cells in epithelia of skin, hepatic bile duct infiltration bronchial mucosa.
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GVHD increased when immunocompetent donor tissues are transferred to immunoincompetent
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like babies
immunosuppresive therapies immunodeficient patients |
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Bone Marrow transplant
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stem cells
lots of CD34 cells helpful to replace immune system |
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