Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
What do A and B (blood type) genes encode?
|
glycosyltransferases that convert the glycolipids on erythrocytes to A or B antigens
|
|
|
Describe Major Transfusion Reaction
|
destruction of introduced RBC by pre-existing antibodies or complement
|
|
|
where are ABO antigens present?
|
RBC's and solid organs
|
|
|
Where is Rh found?
|
Protein found almost exclusively on RBCs
|
|
|
Why does Rh Rejection happen, but no ABO rejection during pregnancy?
|
Rh is protein, induces secondary response, IgG (crosses placenta); ABO antigens are sugars, induce weak T-independent Bcell response, no isotype switching, IgM which doesn’t cross placenta
|
|
|
3 types of MHC Matching
|
Serological typing w/ many different monoclonal antibodies, DNA/PCR typing, Mixed Lymphocyte Reaction
|
|
|
How do you do Mixed Lymphocyte Reaction?
|
mix lymphos from both individuals, MHCII from one individual will stimulate strong proliferation in lymphos, mease relative increase in proliferation
|
|
|
Disadvantage of Mixed Lymphocyte Reaction?
|
results take 5 days, by then cadaveric organs will have died
|
|
|
What is Cross-Matching?
|
Patient's serum mixed with donor's cells and cytotoxicity determined, for hyperacute rejection
|
