Transplant**

Front 1

Skin Graft Types

Back 1

Isograft : Identical twins

Autograft : within an individual

Allograft : non-identical

Xenograft : Between species

Front 2

Graft Rejection: Immunological Reactions

Back 2

Need to overcome the immunogenetic barrier for transplant to be accepted.

1st Set: 10-14 days An unprimed host

2nd Set: 5-6 days Same donor host

- Memory and Specificity

Front 3

Autograft Acceptance

1.

2.

3.

Back 3

1. Revascularization : 3-7 days
2. Healing : 7-10 days
3. Resolution : 12-14 days

Front 4

First Set Rejection

1.

2.

3.

Back 4

1. Revascularization : 3-7 days
   
2. Cell Infiltration : 7-10 days
3. Thrombosis and necrosis : 10-14 days

Front 5

2nd Set Rejection:

1.

2.

Back 5

1. Cell Infiltration : 3-4 days
   
2. Thrombosis and necrosis : 5-6 days

Front 6

Cells involved in rejection

Back 6

• T cells
• Antibodies

Class II differences produce a MLR

Front 7

Catergories of Rejection

Back 7

• Hyperacute (within minutes)

-Due to preformed Ab

-Prevent by cross-matching

• Acute early (Up to 10 days)

-Due to Tc

• Acute late (11days - weeks)

-Due to Ab & C' (platelet aggregation)

• Chroin/ Insidious and late (months - years)

Front 8

Prevent Graft Rejection

Back 8

• Avoid major transplantation antigens

- Human Leukocyte Antigen (HLA)

- ABO blood group

• Immunosuppressants

- Anitmiotics, Steroids

• Match tissue types

- Matching HLA-DR is most important

Front 9

Bone Marrow Transplant: Autogenic

Back 9

1. Harvest sample of bone marrow
   
2. Treat with agents; destroy leukemic cells
3. Intravenous injection of purified stem cells

Destroy patient's remaining bone marrow and leukemic cells before transplantation.

Front 10

Bone Marrow Transplant: Allogenic

Back 10

1. Collection
2. Processing - concentrated & prep. for feeze
3. Cryopreservation - Preserved by freezing
4. Chemotherapy
5. Infusion