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10 Cards in this Set
- Front
- Back
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Serotonin is 5HT
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This slows neuronal impulse flow through serotonin neuron
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5HT begins with tryptophan
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POSTSYNAPTIC 5HT1A receptors INHIBIT cortical pyramidal neurons and regulate hormones, cognition anxiety and depression
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5HT is terminated when it is enzymaticlly destroyed by MAO
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Postesynaptic 5HT2A receptors EXCITED cortical pyramidal neurons, enhance glutamate release and INHIBIT DOPAMINE release
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Serotonin has many different RECEPTOR subtypes
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5HT2C regulate dopamine and norepinephrine release
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Two key PRESYNAPTIC receptors
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5HT1A and 5HT2A have opposite actions in regulating dopamine release
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5HT1A and 5HT1B/D
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5HT1A act as accelerator for dopamine release
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5HT1B/D is on axon terminal and is terminal AUTORECEPTOR
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5HT2A receptors act as a brake on dopamine release (on dopamine neurons)
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5HT on this autoreceptor causes a blockade of 5HT release
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When 5HT1A autorreceptors are activated this inhibits serotonin release
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An antagonist (blocks autoreceptor) promotes 5HT release
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This means 5HT2A receptors can not be activated and dopamine brakes are NOT applied.
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When 5HT is detected in dendrites and body it occurs via a 5HT1A receptor, somatodendritic autoreceoptor.
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5HT2A antagonism makes an antipsychotic "atypical" thus giving a "mixed" effect from medication
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