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8 Cards in this Set
- Front
- Back
t(9,22)
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Philadelphia Chromosome. CML bcr-abl hybrid ==> inc tyrosine kinase activity. Imnatib
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t(8,14)
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Burkitt's lymphoma. c-myc on Ig heavy chain (ch14). Oncogene ==> growth
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t(11,14)
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Mantle cell lymphoma. Cyclin D1 activation.
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t(14,18)
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Follicular lymphoma. bcl-2 activation ==> bcl-2 inhibits apoptosis
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t(15,17)
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AML M3 promyelocytic. Responds to all trans retinoic acid
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t(8,21)
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AML M7 megakaryocytic. Pts with Down syndrome < 5yo
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t(12,21)
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ALL. Downs syndrome >5yo
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t(11,22)
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Ewings Sarcoma. Malignant. Neuroectoderm cells. Diaphysis of long bones. Onion skin on Xray
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