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8 Cards in this Set

  • Front
  • Back
t(9,22)
Philadelphia Chromosome. CML bcr-abl hybrid ==> inc tyrosine kinase activity. Imnatib
t(8,14)
Burkitt's lymphoma. c-myc on Ig heavy chain (ch14). Oncogene ==> growth
t(11,14)
Mantle cell lymphoma. Cyclin D1 activation.
t(14,18)
Follicular lymphoma. bcl-2 activation ==> bcl-2 inhibits apoptosis
t(15,17)
AML M3 promyelocytic. Responds to all trans retinoic acid
t(8,21)
AML M7 megakaryocytic. Pts with Down syndrome < 5yo
t(12,21)
ALL. Downs syndrome >5yo
t(11,22)
Ewings Sarcoma. Malignant. Neuroectoderm cells. Diaphysis of long bones. Onion skin on Xray