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11 Cards in this Set

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What drug blocks initiation?
Aminoglycosides

Blocks the small 30S subunit
and doesn't let the tRNA hook into the P site
What is another drug that blocks initiation?
Tetracycline
What is the effect of tetracycline?
Blocks AminoAcyl-tRNA from binding to the A site

30S subunit
What is the neumonic for translation blocker drugs?
buy AT 30 CELL at 50
What blocks peptidyl transferase in the Large 50S subunit?
Chloramphenicol
What is the action of peptidyl transferase?
it forms peptide bond on the A site

takes the tRNA a.a. from the P site to the A site
Who blocks transLOcase?
macrOLides
What is the function of macrOLides?
blocks the movement of tRNA from A site to the P site for elongation
What 3 drugs block the 50S subunit?
Chloramphenicol
Erythromycin (Macrolides)
Lincomycin
CLindamycin
What two bacteria inhibit translation?
Diphtheria toxin
Pseudomonas
Where exactly do diphtheria and pseudomonas act?
EF-2 via ADP ribosylation reaction