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11 Cards in this Set
- Front
- Back
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What drug blocks initiation?
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Aminoglycosides
Blocks the small 30S subunit and doesn't let the tRNA hook into the P site |
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What is another drug that blocks initiation?
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Tetracycline
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What is the effect of tetracycline?
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Blocks AminoAcyl-tRNA from binding to the A site
30S subunit |
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What is the neumonic for translation blocker drugs?
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buy AT 30 CELL at 50
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What blocks peptidyl transferase in the Large 50S subunit?
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Chloramphenicol
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What is the action of peptidyl transferase?
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it forms peptide bond on the A site
takes the tRNA a.a. from the P site to the A site |
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Who blocks transLOcase?
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macrOLides
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What is the function of macrOLides?
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blocks the movement of tRNA from A site to the P site for elongation
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What 3 drugs block the 50S subunit?
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Chloramphenicol
Erythromycin (Macrolides) Lincomycin CLindamycin |
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What two bacteria inhibit translation?
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Diphtheria toxin
Pseudomonas |
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Where exactly do diphtheria and pseudomonas act?
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EF-2 via ADP ribosylation reaction
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