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87 Cards in this Set
- Front
- Back
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weight min to donate
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50kg or 110lbs
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hgb to donate
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125g/l
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hct to donate
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0.38l/l
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blood pressure to donate
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systolic <180mm <100mm Hg
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pulse to donate
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>50<100 beats/min
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temperature to donate
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<37 degrees
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4 wks deferred from donating
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rubella vaccine
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permenantly deferred from donating
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had hepatitis B
history of CJD or 1st degree family member with CJD 3+mo in france or united kingdom 5+ years in western europe human pituitary growth hormone or human origin leukemia lymphoma, heart disease, chronic high blood pressure, bleeding disorders, cancer, viral hepatitis, pos for HBsAg, hep C, HIV IV drug use man sex with man malaria (cellular products) tegison (acne med) |
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12 months deferral from donating
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sex with a prostitute
recieved HBIG recipent of human tissue or blood products syphillis or gonorrhea sex with partner has hep in jail for more than 48 h injection of illegal steriods |
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6 month deferral from donating
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post partum
tattoo or piercing exposure (needle stick or splash) |
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increase or decrease in storage with CPDA-1- pH, 2,3-DPG, plasma hgb, plasma K, ATP
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pH- decreased
2,3-DPG- decrease Plasma hgb- Increase Plasma K- Increase ATP- decrease |
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1 year exp
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ffp, cryo(frozen)
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5 day exp
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platelet pheresis 20-24 degrees
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35 day exp
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CPDA-1 RBCs 1-6 degrees
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42 day exp
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RBCs with AS-3 1-6 degrees
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24 hours exp
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granulocytes 20-24 degrees
packed RBCs prepared by open system 1-6 degrees |
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purpose of trisodium citrate
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anticoagulant
chelates calcium inhibits glycolysis buffer |
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purpose of dextrose
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nutrient
substrate for glycolytic process of rbcs which produce ATP |
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purpose of sodium phosphate
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buffer
maintains high pH which is necessary to maintain 2,3-DPG levels for O2 dissociation |
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purpose of adenine
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substrate from which rbcs can synthesize ATP
improved viability diluent |
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what is given for hemophilia A
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factor VIII (8) concentrate
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what is given for hemophilia B
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factor IX (9) concentrate
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what is given for fibrinogen deficieny
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cryoprecipitate
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what is given to a bone marrow transplant patient with anemia unresponsive to iron and vitamin B12 therapy
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irradiated RBCs
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what is given for increasing O2 carrying capacity
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rbc
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what is given for vit k deficiency and hemorrhage
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fresh frozen plasma
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also called AHF
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cryoprecipitate
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what is given for a directed donation from a blood relative
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irradiated RBCs
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what is given for repeated febrile transfusion reactions
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leukocyte reduced rbcs
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what is given for anaphylaxis
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washed or deglycerolized rbcs
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what is given for life threatening neutropenia
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granulocytapheresis
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what is given for needle stick accident with infectious blood (hep B)
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hepatitis B immune globulin
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what is given for immunodeficiency
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immune globulin
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what is used for dilution of RBCs
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0.9%saline
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4 examples of when platelet transfusion would be contradicted
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TTP
HUT ITP post transfusion purpura |
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what is copper sulfate used for
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fast screening method for hgb. if the blood drops within 15 sec. able to donate
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frequency of donation
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56 days or 8 weeks
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3 week deferral for donation
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hep b vaccine
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2 day deferral
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hep a influenza polio (toxoid or vaccines containing killed materials)
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3 month deferral
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chicken pox
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3 year deferral
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lived in endemic area
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1 year deferral
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travelled to endemic area
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volume of bag
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450 mls +- 10%
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autologous donation
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donate for self
never put on the regular shelf no age limit min 25kg or 55lbs hgb 110g/l hct 0.33l/l |
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normovolemic hemodilution
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units collected from patient immediately before surgery
reinfused by colloid or crystalliod within 8 h |
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intraoperative salvage
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blood is collected from operative site or extracorpeal circut is centrifuged washed and reinfused through a filter within 6 h
used for cardiac thoracic, major orthopedic and cardiac surgeries |
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postoperative salvage
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collected from surgical site , body cavities joint spaces by a drainage tube and reinfused within 6 h
used for orthopedic and cardiac surgeries |
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long-term storage
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autologous blood may be stored frozen for up to ten years
used for patients with difficult blood to match |
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directed donation
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chosen donor by recipent.
if from blood relative it must be irradiated |
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designated donation
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donor is selected for recipient for medical reasons
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apheresis donation
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unit is centrifuges and a component is taken and the rbcs are reinfused
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syphillis antibody
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reagin
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purpose of citric acid
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keeps pH of 5.6
lessens dextroses tendency to carmelize during heat sterilization makes pH of 7.2 @4 degrees |
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pH decrease
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blood =more acidic
build up of lactic and pyruvic acid from glycolysis |
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ATP decrease
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decrease rbc viability
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2,3-DPG decrease
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decrease ability to release O2
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K in plasma increase
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exp blood
k can cause toxicity to patients |
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labile coag factors decrease
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some decrease rapidly upon storage
factor 5 and 8 |
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platelet function decrease
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platelets tend to aggregate
must be kept at RT and moving |
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leukocyte viability decrease
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lose viability after 6 h
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4 reasons for transfusion
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restore or maintain
O2 carrying capacity blood volume coag properties leukocyte function |
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RBC LR deglycerolized
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frozen up to 10 years
rare blood groups 24 h after thaw at 1-6degrees |
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RBC LR CP2D
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21 days 1-6degrees
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RBC LR CP2D + AS3
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42 days 1-6 degrees
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open system RBC
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24 h 1-6 degrees
4 h 20-24 degrees |
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what is given for TTP
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FFP
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FFP LR/apheresis/FP LR frozen/thawed storage
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frozen 1 year -18 or colder
thawed 24h at 1-6 degrees use asap |
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FFP must be separated from cells within
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8 hours
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FP must be separated from cells within
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24h
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platelet LR/apheresis storage
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5 days 20-24 degrees
4hours in open system(pooling) |
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platelet pH and amount of platelets in unit
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platelet function is impaired below pH 6.0
55x10^9 platelets per unit |
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platelet apheresis
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300x 10^9 in 200-400ml plasma
less than 5-10^6 leukocytes per bag |
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cryoprecipitate Storage
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frozen 1 year -18
thawed 4 hours 20-24degrees |
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what is in cryo
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factor 8, vWF, Factor 13, fibronectin, fibrinogen
80units of F8 in 5-15 ml of plasma at least 150mg of fibrinogen |
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albumin is used for
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volume replacement unresponsive to crystalloid
burns after removal of fluid, plasma exchange, severe necrotizing pancreatitis |
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intravenous immune globulin
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sterile solu'n of human protein that is manufactured from pooled plasma and has been solvent treated to reduce virus'
treats ITP, kawasaki syndrome etc |
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winRho Rh immune globulin
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freeze dried gamma globulin fraction
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irradiated product storage
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increased plasma hgb and K
28 days after irradiation or expiry date |
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keep donor segments for ____ after transfusion
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7 days
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intravascular hemolysis
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antibody bound complement to C9
usually ABO abs |
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extravascular hemolysis
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antibody bound donor cells with out binding complement removied by spleen
usually clinically significant Abs |
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Delayed HTR
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5-14 days post transfusion
caused by weak undetectable Ab usually Kidd, Rh or duffy |
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febrile non hemolytic
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interaction btw plasma in recipient and transfused lymphocytes, granulocytes, or platelets
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urticarial (allergic)
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donor plasma protein or globulin causing an allergic reaction
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anaphylactoid
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IgA deficient patient who has anti- IgA
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graft v host
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infusion of immunocompitant t lymphs into a patient who is incapable of rejecting them
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transfusion related acute lung injury
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donor Ab react with ag on patient leukocytes causing aggregation in the pulmonary vasculature
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