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24 Cards in this Set
- Front
- Back
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How did the name "Rh antigen" derived?
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Testing was done on Rhesus monkeys in 1939.
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What are Rh ags made of?
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Proteins
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What are the 5 main ags and their frequencies in the Rh system?
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D 85%
C 70% E 30% c 80% e 98% |
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On which chromosome is the Rh gene located?
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1
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What genes are present in the 2 loci of Rh genes?
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First locus: RHD
Second locus: RHCE |
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How does Rosenfield classify the Rh alleles?
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D = Rh1
C = Rh2 E = Rh3 c = Rh4 e = Rh5 |
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How does ISBT classify the Rh alleles?
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Rh system = 004
Each ag has 3 digit code: D = 001 C = 002 E = 003 c = 004 e = 005 |
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How does Fisher-Race classify the Rh alleles?
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CDE CDe cDE cDe
CdE Cde cdE cde |
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How does Wiener classify the Rh alleles?
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using R or r as notation
R1=CDe R2=cDE R0=cDe Rz=CDE r'=Cde r"=cdE r=cde ry=CdE |
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What is the frequency of the Rh phenotype in Blacks?
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R0, r, R1, R2
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What is the frequency of the Rh phenotype in Whites?
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R1, r, R2, R0
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Why is R2R2 (cDE cDE) has more D ags than R1R1 (CDe CDe)?
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C in trans with D
there's suppression of D |
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3 possible causes of weaker D expression.
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1. Genetic
2. Position type 3. Mosaic type |
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Weak D is used to detect?
Genetic Position type Mosaic type |
Genetic
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Monoclonal anti-D is sufficient to detect:
Genetic Position type Mosaic type |
Position type
Mosaic type |
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On which patients do we need to use weak D testing?
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Mom/Baby
Donors |
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Why must donor's blood be tested for weak D?
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because recipients would make anti-D to the blood if transfused
try to avoid antibody product at all cause |
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The significance in:
Cw, f, G, Lw |
Cw: rare allele of C and c
f: present when c and e are inherited on the same chromosome G: present when D or C are inherited Lw: high freq ag |
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The significance in:
Rh null D-deletion |
Rh null: no Rh ags at all
(have RBC membr abnormailities, leading to hemolytic anemia) D-deletion: -D- -D- stronger D ag activity |
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What type of Ig is present in Rh?
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IgG1
IgG3 |
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What is the optimal reaction phase for Rh reactions?
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37oC
IAT |
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What is the effect if potentiators are used in the Rh reaction?
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enhanced
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Rh antibodies are formed by?
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transfusion or pregnancy exposure
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Do Rh antibodies activate complement?
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NO!
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