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12 Cards in this Set
- Front
- Back
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Febrile nonhemolytic transfusion rxn |
Increase temp 1°C or 2°F. Cytokines released by lymphocytes. Reduce incidence with leukoreduction |
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Allergic transfusion reaction |
IgE mediated. Treat with antihistamines or epi if anaphylaxis. IgA deficient may need IgA deficient or washed units |
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Intravascular hemolysis |
ABO incompatibility, rarely Kidd. Fever, chills, pain at infusion site, hypoTN, DIC back pain. +DAT, pink serum, schistocytes, hemoglobinuria |
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Extravascular hemolysis |
Non-ABO. High bili, anemia. +DAT, spherocytes |
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Reporting time to FDA for fatality in transfusion rxn |
24 hr by phone; within 7 days in writing |
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DHTR and DSTR |
DHTR- hemolysis after 24hr. DSTR- new alloAb without hemolysis. +DAT (mf), high bili, microspherocytes. Kidd may be severe intravascular DHTR. |
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Septic (bacterial contamination) |
Platelets more common but RBCs higher mortality. Platelets- staph. RBCS- gram negs esp Yersinia. Reason first 15-30 mL of donated blood are diverted (skin plugs). |
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TAGVHD |
Donor lymphocytes attach host —> dermatitis, diarrhea, high LFTs, pancytopenia. May happen if donor is HLA XX/XX and recipient is HLA XX/YY. Prevent with irradiation. |
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TRALI |
Most common cause of fatality. B/l lung infiltrates, PaO2:FiO2 < 300, O2 sat < 90% within 6 hrs. Donor antigranulocyte and antiHLA, esp due to plasma/platelets from multiparous female donor. |
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Post transfusion purpura |
Multiparous woman with low plts after RBC or plt transfusion. Due to anti-HPA1a (Pla1). Treat with IVIg. |
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Platelet refractoriness |
Platelet count increment < 7500 PCI = (increment x BSI/#plts transfused x10^11) HLA alloimmunization, splenomegaly are causes. |
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TACO |
CHF, elevated BNP, elevated pulmonary capillary wedge pressure. Volume overload. Go slow and diurese |
