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34 Cards in this Set
- Front
- Back
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Three reasons prestorage leukocyte reduction is more effective than bedside reduction?
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1. Reduces leukocytes before they can be activated
2. Provides better quality control 3. Avoids rare reactions to bedside filters |
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Shelf life of ACD or CPD
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21 days
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Shelf life of CPDA
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35 days
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Shelf life of Adsol, AS, opticel
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42 days
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How do you prepare frozen red cells for transfusion?
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washed and deglycerolized
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What is in cryo?
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actor VIII, vwf, and fibrinogen
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At what intervals must blood component storage, freezers, and platelet incubators be monitored for temperature?
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4 hours or less
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What are the significant IgG antibodies towards?
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Rh, Kell, Kidd, Duffy
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When do you have to test for weak D?
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On the donor
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What are the three phases of antibody identification tests?
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Immediate spin
Incubation at 37 Antihuman globulin testing |
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Who should you avoid giving O platelets to?
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A non-group O patient, as O donors have high titer anti A or B
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What neutralizes lewis antibodies?
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Saliva from lewis antigen positive individuals
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What neutralizes anti-p1
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echinococcus hydatid cyst fluid or pigeon egg
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What is the dose for RhIG and how many platelet transfusions will it gover
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300 micrograms, 5-6 transfusions
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How do you get A antigen from H?
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Addition of N-acetylgalactosamine
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How do you get B antigen from H?
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Addition of galactose
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What agglutinates A1 red cells?
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Dolichos biflorus lectin
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How does Acquired B appear on typing?
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Forward types as AB, and anti-B on reverse typing
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Individuals who are group O secretors have what association?
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Gastric ulcers and gastric cancer as a result of the fact that type 1 H and Le(b) are receptors for several strains of H. pylori
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What is mycoplasma pneumonia associated with?
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Auto-anti-I
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What are some causes of auto anti-i?
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Infectious mono and alcoholic cirrhosis
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What is paroxysmal cold hemoglobinuria associated with?
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auto-anti-P
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What infection is the P antigen associated with?
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It is the receptor for parvovirus B19
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Anti-c is often found with?
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Anti-E
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Patients with anti-c or anti-e should avoid what type of RBCS?
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Rh-Negative red cells because these are highly likely to be ce/ce
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What % of blood have Kell antigen?
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9%
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How do you remember the location of MNS and U antigens?
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BUS MAN
- S/s and U are on glycophorin B M, N are on glycophorin A |
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Fy(a-b-) populations have what advantage?
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Resistant to P.vivax malaria
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How fast must blood product be used after release?
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Within 4 hours or returned within 30 minutes
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What are some signs and symptoms of acute hemolytic reactions?
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Hypotension, red hurine, red plasma, flank pain, acute onset DIC, sense of impending doom
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How do delayed HTRs present?
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Unexplained decreases in hemoglobin/hematocrit, unexplained increase in unconjugated bili
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Mechanism of TRALI non cardiogenic edema?
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Granulocyte or HLA antibodies from the donor or neutrophil sequestration in the pulmonary capillary bed
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Mechanism of PTP
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Anamnestic production of platelet-specific antibody, often directed against HPA-1 platelet antigen
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What is an appropriate initial dose of FFP?
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10 ml/kg
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