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33 Cards in this Set
- Front
- Back
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Shelf life of whole blood or pRBC with ACD, CPD, or CP2D?
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21 days
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Shelf life of whole blood or pRBC with CPDA-1?
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35 days
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Shelf-life of pRBC with additive solution (e.g. AS-1, AS-3, or AS-5)?
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42 days
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Storage temperature for whole blood or pRBC?
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1-6 C
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Shelf life for frozen RBC? What is the storage temperature? What is the shelf life after thawing?
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1. Frozen RBC: 10 years
2. Storage temperature: -65 C 3. Shelf life after thawing: 24 h |
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Shelf life for washing RBC? Storage temperature?
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24 h at 1-6 C
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Shelf life of platelets? Storage temperature?
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5 days at 20-24 C with gentle agitation
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Shelf life of granulocyte transfusion? Storage temperature?
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24 h at 20-24 C without agitation
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Shelf life of FFP and storage temperature? (3)
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1. 1 year at -18 C
2. 7 years at -65 C 3. 24 h at 1-6 C (after thaw) |
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Shelf life of cryo and storage temperature? (3)
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1. 1 year at -18 C
2. 6 hours at 20-24 C (after thaw single donor) 3. 4 hours at 20-24 C (pooled products) |
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What is the maximum hematocrit for RBC?
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Less than 80%
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What is the maximum WBC count for leukoreduced RBC or leukoreduced apheresis platelets?
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Less than 5 x 10^6
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What is the minimum platelet count for 1 unit of platelet concentrate?
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At least 5.5 x 10^10
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What is the maximum WBC count for leukoreduced platelet concentrate? (Clue: it is 1/6 of that for leukoreduced RBC or apheresis platelets.)
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Less than 8.3 x 10^5
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What is the minimum platelet count for apheresis platelets?
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At least 3 x 10^11
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What is the minimal WBC count for granulocyte infusion?
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1 x 10^10
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What are the components of cryo and what are the minimal concentrations?
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Factor 2 (fibrinogen): at least 150 mg
Factor 8 at least: 80 IU VWF: 80-120 IU Factor 13: 40-60 IU |
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What is the expected bump in hemoglobin and hematocrit for 1 unit of RBC?
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HB = 1
Hct = 3 |
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What is the typical volume for the following products?
RBC Platelet concentrate platelets Apheresis platelets FFP Cryo |
RBC: 250 mL (350 mL with additives)
Platelet concentrate platelets: 40-60 mL Apheresis platelets: 100 mL FFP: 200-250 mL Cryo: 15 mL |
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How do you dose platelet concentrate platelets in adults in babies?
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Adults: 1 unit per 10 kg body weight
Babies: 10-15 mL/Kg |
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Is leukoreduction sufficient for people at risk for GVHD?
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No, these need to be irradiated.
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What is the shelf life of washed RBC? What about platelets?
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RBC: 24 h
Plt: 4 h |
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What is the shelf life of thawed/deglycerolized frozen RBC? What temperature should it be stored at?
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24 h at 1-6 C.
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What is the clinical presentation of TA-GVHD?
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1. Fever 7-10 days after transfusion
2. face/trunk rash that spreads to extremities 3. Diffuse mucositis with N/V, watery diarrhea 4. Hepatitis 5. Pancytopenia, aplastic anemia |
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What dosage of radiation is given for irradiated products?
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1. 2500 cGy ("rad") at center of bag and
2. 1500 cGy in all parts of bag |
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Which immunocompetent recipient needs irradiated products?
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HLA "matched" unit.
NOTE: E.g. close relatives - if recipient is heterozygous and donor is homozygous for and they share an allele, the recipient will not be mount a response to the donor lymphocytes. |
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What is a product's shelf life after irradiation?
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28 days after irradiation or regular expiration date, whichever comes first.
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What do these people have in common:
Organ transplant recipients Term neonates Aplastic anemia AIDS |
They don't have much risk for GVHD but often get irradiated products anyway.
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What is "thawed plasma"?
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Thawed FFP is only good for 24 h. After 24 h, the product can be relabeled as "thawed plasma" and kept at 1-6 C for up to 5 days
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What is "liquid plasma"?
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"liquid plasma" is separated from whole blood at any point up to 5 days after expiration, stored at 1-6 C for up to 5 days AFTER whole blood expiration date.
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Is irradiation of granulocyte transfusion allowable?
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Yes, may irradiate granulocyte transfusion to prevent GVHD because the radiation kills lymphocytes but not granulocytes for some reason.
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What is the shelf life of granulocyte transfusion? Stored at what temperature?
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24 h at 20-24 C
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Do you need to type and crossmatch granulocyte transfusions?
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Yes, there are a lot of RBC in there.
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