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28 Cards in this Set

  • Front
  • Back
Retrovirus advantages
high efficiency
integration --> long term expression
Retrovirus disadvantages
possible insert mutations
requires proliferating cells
relatively small DNA insert
Lentivirus advantages
No requirement for cell division
integration --> long term expression
Lentivirus disadvantages
small insert
Adenovirus advantages
broad range of target cells
no requirement for cell division
no integration --> no mutations
Adenovirus disadvantages
transient residence in cells
immunogenic --> inflammation
Adenoassociated virus advantages
both integration extrachromosomal maintainance
possible site specific integration
Adenoassociated virus disadvantages
small transgene insert
liposomes advantages
no infection risk
no limit on DNA content
potential for receptor targeting
liposomes disadvantages
low efficiency
limitations on targeting
transient expression
lysomal uptake --> degradation
adv: high efficiency
common retrovirus
adv: integration --> long term expression
retrovirus
lentivirus
adv: no requirement for cell division
lentivirus
adenovirus
adv: broad range of target cells
adenovirus
adv: no integration --> no mutations
adenovirus
adv: both integration and extrachromosomal maintainance
adeno-associated virus
adv: possible site specific integration
adeno-associated virus
disadv: possibel insert mutations
common retrovirus
disadv: requires dividing cells
common retrovirus
disadv: relatively small DNA insert
common retrovirus
lentivirus
adeno-associated virus
adv: no infection risk
synthetic vectors
liposomes
nanoparticles
adv: no limit on DNA content
synthetic vectors
liposomes
nanoparticles
adv: potential for receptor targeting
synthetic vectors
liposomes
nanoparticles
disadv: low efficiency
synthetic vectors
liposomes
nanoparticles
disadv: limitations on targeting
synthetic vectors
liposomes
nanoparticles
disadv: lysomal uptake and degradation
synthetic vectors
liposomes
nanoparticles
disadv: transient expression
synthetic vectors
liposomes
nanoparticles

Adenovirus (transient residence in cells
disadv: immunogenic inflammation
adenovirus